The synthesis and characterization of a novel potassium chloride-fluoridated hydroxyapatite varnish for treating dentin hypersensitivity

Dental Materials Journal
Yossakit LochaiwatanaNoppakun Vongsavan

Abstract

Dentin hypersensitivity is treated using materials that occlude the dentinal tubules or release potassium ions that induce nerve desensitization. In this study we formulated a novel varnish containing potassium chloride and fluoridated hydroxyapatite and evaluated its physical properties and cytotoxicity. Potassium ion release from the varnish was measured. Dentin permeability was evaluated by measuring the hydraulic conductance of etched dentin discs treated with the varnish. The direct contact test and MTT assay were performed to evaluate the varnish's cytotoxicity. We found that the varnish released potassium ions over 6 h, and demonstrated a statistically higher reduction in dentin permeability compared to commercial fluoride varnish or control. Dentin disc scanning electron microscopy images demonstrated occluded dentinal tubules in the novel varnish group after brushing. The cytotoxicity tests indicated the varnish was biocompatible with gingival and pulpal fibroblasts. We propose the novel varnish is a potential material for use in hypersensitivity management.

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Citations

Mar 2, 2017·European Journal of Oral Sciences·Elena M VaroniLia Rimondini
Oct 16, 2019·Dental Materials Journal·Woradej PichaiaukritSomporn Swasdison
Apr 10, 2017·Lasers in Medical Science·Anely Oliveira LopesAna Cecília Correa Aranha
Jun 1, 2018·International Journal of Dentistry·Luiza Pereira Dias da CruzDavid G Gillam
Feb 26, 2021·BioMed Research International·Mohideen S FarookMarwah Berkathullah
Apr 16, 2021·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·Sergio López-GarcíaDavid García-Bernal
Jun 13, 2021·Journal of Dentistry·Bruna de Oliveira ReisPaulo Henrique Dos Santos
Dec 30, 2021·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Vita ZaliteJanis Locs

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