Jan 1, 1976

The synthesis and properties of N6-substituted 2-amino-purine derivatives

Acta biochimica Polonica
C Janion

Abstract

1. The synthesis, ultraviolet absorption spectra, and behaviour in alkali of N6-methoxy-, N6-methyl, hydroxy-, and N6-hydroxy-2-aminopurines have been described 2. N6-Methoxy-2-aminopurine riboside 5'-pyrophosphate has been prepared and used for polymerization with polynucleotide phosphorylase. 3. The copolymer containing N6-methoxy-2-aminopurine riboside and adenosine residues has been obtained; attempts to synthesize the homopolymer have not been successful. 4. All the purine analogues synthesized have been tested and shown to act mutagenically on Salmonella typhimurium TA1530.

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Mentioned in this Paper

Adenosine
Structure-Activity Relationship
Purine Nucleotides
PNPT1 gene
Copolymer
Spectrophotometry, Ultraviolet
Purine derivatives, peripheral vasodilators
Pyrophosphate
2-Aminopurine
Homopolymer

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