PMID: 5914692Feb 1, 1966

The synthesis of DNA, RNA, and nuclear protein in normal and tumor strain cells. 3. Mouse ascites tumor cells

The Journal of Cell Biology


Interferometric and photometric measurements have been made on replicating mouse ascites tumor cell cultures. From a study of the relations between successive physical measurements on individual cells, it was found that whereas the net syntheses of nuclear RNA and nuclear protein are closely associated during interphase, they are dissociated from DNA replication to a significant extent. These results agree with others reported in replicating cell strains derived from tumors. In auxiliary experiments an attempt was made to block the initiation of DNA synthesis by X-irradiation: although large amounts of nuclear protein accumulated in some cells in the absence of DNA synthesis, the inability to hold the DNA block for an interphase time prevented a quantitative analysis of the results.


Jan 1, 1968·Zeitschrift für Krebsforschung·S ComorosanD Sandru
Apr 1, 1979·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·U K Ehmann, K T Wheeler
Jul 1, 1969·Experimental Cell Research·J W Harris, H M Patt

Related Concepts

Carcinoma, Ehrlich Tumor
Cell Nucleus
DNA, Neoplasm
Neoplasm Proteins
Effects of Radiation
RNA, Neoplasm

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