Dec 1, 1980

The synthesis of folate-binding protein in lymphocytes during transformation

British Journal of Haematology
M da Costa, M Sharon

Abstract

The blast transformation of human lymphocytes exposed to phytohaemagglutinin was associated with an increase in the intracellular concentration of a folate-binding protein. The protein was measured by a radioimmunoassay and by immunofluorescent microscopy using an antiserum raised against purified folate-binding protein prepared from chronic myelogenous leukaemia cells. Because it has been previously shown that protein-bound folate cannot function as a cofactor or substrate, the synthesis of this binder during some phase of the replicative cycle may serve to modulate folate-dependent RNA and DNA synthesis by controlling the concentration of free folate.

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References

Mentioned in this Paper

Immunofluorescence Assay
Lymphocytes as Percentage of Blood Leukocytes (Lab Test)
Hormone Receptors, Cell Surface
Protoplasm
Lymphoid Cells
Immune Sera
Lymphocyte Activation
Binding Protein
Folate
Microscopy

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