PMID: 16637286Apr 28, 2006Paper

The synthesis of immunomodulating peptide alloferon, the active component of the antiviral drug allokine-alpha

Bioorganicheskaia khimiia
M V SidorovaV N Bushuev

Abstract

Two variants of the synthesis of tridecapeptide alloferon, the active principle of antiviral preparation allokine-alpha, were developed on the basis of fragment condensation in solution or on the Merrifield resin. The solid phase variant of the synthesis was shown to be more technological; it allows the preparation of the product at a higher total yield (40% vs. 17% for conventional synthesis in solution from the starting derivatives of the C-terminal dipeptide). The by-products formed during the synthesis of alloferon were identified.

References

Feb 29, 1988·Biochemical and Biophysical Research Communications·I Y SakharovM I Titov
Jan 1, 1994·Methods in Molecular Biology·C G Fields, G B Fields

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Citations

Mar 26, 2008·Molecular and Cellular Biochemistry·Myung-Jeom RyuCheolju Lee

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