The synthesis of N-acetyl-leukotriene E4 and its effects on cardiovascular and respiratory function of the anesthetized pig

Prostaglandins
A FosterL G Letts

Abstract

The effects of the putative biliary metabolite of the peptido-leukotrienes, N-acetyl-leukotriene (LT) E4 has been investigated in the anesthetized pig. Intravenous bolus doses of synthetic N-acetyl-LTE4 produced minimal respiratory and cardiovascular actions in the pig. N-acetyl-LTE4 was approximately 100-fold less active than LTC4. The actions of N-acetyl-LTE4 were not blocked by pretreatment of the animals with indomethacin (5 mg/kg iv) or with a selective LTD4 antagonist L-649,923 (5 mg/kg plus 2 mg/kg/hr iv). In summary, N-acetyl-LTE4 exerts weak actions in the pig which is consistent with the acetylation process being a mechanism of detoxification.

References

Feb 1, 1990·Prostaglandins·J Y TsangR R Schellenberg
Jan 1, 1985·Prostaglandins·P J PiperL J McLeod
Jan 28, 1985·FEBS Letters·W HagmannD Keppler
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Citations

Oct 17, 1987·Biochimica Et Biophysica Acta·A FosterL G Letts
Feb 9, 1988·European Journal of Pharmacology·A L SirenG Feuerstein
Jan 1, 1987·Advances in Enzyme Regulation·D KepplerA Guhlmann
Jan 1, 1991·Annals of the New York Academy of Sciences·D KepplerM Huber
Jul 1, 1991·The American Review of Respiratory Disease·R H GundelC D Wegner
Mar 20, 2012·Journal of Neuroinflammation·Jonathan BertinMichel J Tremblay
Jun 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A GuhlmannD Keppler
May 1, 1989·Prostaglandins, Leukotrienes, and Essential Fatty Acids·A FosterJ Rokach
Nov 13, 1987·Biochemical and Biophysical Research Communications·A FosterG Letts

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