PMID: 6108992Jul 1, 1980Paper

The synthesis of neuroactive amino acids from radioactive glucose and glutamine in the rat retina: effects of light stimulation

Journal of Neurochemistry
M J Voaden, B Morjaria

Abstract

The effect of light stimulation in vitro on the labelling of neuroactive amino acids derived from [14C]glucose or [14C]glutamine in the rat retina has been studied. [14C]Glutamine, at 700 microM, provided about 50% of the tissue pools of glutamate, aspartate, and GABA; and the labelling of these decreased on light stimulation, both in the photoreceptor cells (glu and asp) and in the inner retina (glu, asp, and GABA). In contrast, there were no significant changes in the entry of label derived from [14C]glucose, although similar trends were apparent in the data obtained for the photoreceptor cell layer. The pools may, therefore, be separate. Other results support the contention that glucose is the principal energy source for the retina, its entry into non-amino acid derivates being decreased on light stimulation.

References

Oct 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·S M Wu, J E Dowling
Oct 1, 1978·Journal of Neurochemistry·M J VoadenB Morjaria
Jun 1, 1979·Journal of Neurochemistry·B Morjaria, M J Voaden
Jan 1, 1979·Progress in Brain Research·M J Voaden
Jun 1, 1978·Journal of Neurochemistry·H F BradfordA J Thomas
Oct 1, 1976·General Pharmacology·M J Neal
Jan 1, 1974·Comparative Biochemistry and Physiology. A, Comparative Physiology·K HiroseR Ishida
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Nov 1, 1978·Neuroscience Letters·J C ReubiM Cuénod
Apr 1, 1967·Applied Optics·B Lax, J G Mavroides

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Citations

Mar 1, 1982·Pharmacology, Biochemistry, and Behavior·J E SmithJ D Lane
Nov 1, 1988·Pharmacology, Biochemistry, and Behavior·T MiyauchiJ E Smith
Jan 1, 1980·Neurochemistry International·M J VoadenA C Oraedu
May 1, 1983·Journal of Neurochemistry·M E FreemanJ E Smith
Jun 1, 1997·Acta Ophthalmologica Scandinavica·L Wang, A Bill
Dec 15, 1988·The Journal of Comparative Neurology·G A EngbretsonJ Y Wu

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