The synthesis of the 2,3-difluorobutan-1,4-diol diastereomers.

Beilstein Journal of Organic Chemistry
Robert SzperaBruno Linclau

Abstract

The diastereoselective synthesis of fluorinated building blocks that contain chiral fluorine substituents is of interest. Here we describe optimisation efforts in the synthesis of anti-2,3-difluorobutane-1,4-diol, as well as the synthesis of the corresponding syn-diastereomer. Both targets were synthesised using an epoxide opening strategy.

References

Apr 27, 2002·The Journal of Organic Chemistry·Dörthe Wölker, Günter Haufe
Dec 10, 2009·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Peer Kirsch, Matthias Bremer
May 27, 2010·Beilstein Journal of Organic Chemistry·Luke Hunter
Jul 14, 2010·Beilstein Journal of Organic Chemistry·Bruno LinclauGraham Tizzard
Jul 23, 2013·Angewandte Chemie·Theresa LiangTobias Ritter
Apr 10, 2015·Chemical Reviews·Pier Alexandre ChampagneJean-François Paquin
Jul 23, 2015·Journal of Medicinal Chemistry·Eric P GillisNicholas A Meanwell
Aug 11, 2016·Organic & Biomolecular Chemistry·Damian E YerienAl Postigo

❮ Previous
Next ❯

Citations

Apr 26, 2019·Angewandte Chemie·Claudio F MeyerVéronique Gouverneur
Jun 3, 2021·Chemical Society Reviews·Jeroen B I SapVéronique Gouverneur

❮ Previous
Next ❯

Methods Mentioned

BETA
column chromatography
NMR

Software Mentioned

DAST

Related Concepts

Related Feeds

Alpha-Synuclein Aggregation (MDS)

Alpha-synucleins are small proteins that are believed to restrict the mobility of synpatic vesicles and inhibit neurotransmitter release. Aggregation of these proteins have been linked to several types of neurodegenerative diseases including dementia with Lewy bodies and Parkinson's disease. Here is the latest research on α-synuclein aggregation.

Related Papers

Organic & Biomolecular Chemistry
Thomas J CogswellRodolfo Marquez
Journal of the American Chemical Society
Andreas GansäuerMatthias Otte
World Review of Nutrition and Dietetics
T GORDONOFF, W MINDER
Bruxelles médical
M Lust
The Mississippi Doctor
F J UNDERWOOD
© 2022 Meta ULC. All rights reserved