The synthetic pentasaccharide SR 90107A/Org 31540 does not release lipase activity into the plasma

Thrombosis Research
P HoffmannJ M Herbert

Abstract

The present study was designed to find out whether the synthetic pentasaccharide SR 90107A/Org 31540, which is presently being evaluated in clinical trials as an antithrombotic agent, influences lipoprotein metabolism in rats as determined by plasma triglyceride (TG) lipase activity. A comparison with three clinically used sulphated polysaccharides-unfractionated heparin (UFH), low molecular weight heparin (LMWH) and pentosan polysulphate (PPS)- was performed. UFH evoked a dose-dependent increase in plasma TG lipase activity which plateaued at doses > or = 1 mg/kg i.v.. PPS and LMWH demonstrated a lower efficacy than heparin at 0.3 and 1 mg/kg i.v., but the maximum lipase releasing effect at 3 mg/kg i.v. was identical for UFH, PPS and LMWH. SR 90107A/Org 31540 did not release TG lipase activity at single i.v. doses up to 3 mg/kg. Repeated-dose experiments with SR 90107A/Org 31540 (1 mg/kg s.c. for 9 days) revealed no influence on the lipase releasing effect of UFH (1 mg/kg i.v. on day 10). These results demonstrate that SR 90107A/Org 31540 does not influence lipid metabolism in rats through lipase release, suggesting that SR 90107A/Org 31540 may offer an advantage over UFH and LMWH in clinical situations where an anticoagulant/...Continue Reading

References

Nov 12, 1990·Biochimica Et Biophysica Acta·D M Goldberg, T Chajek-Shaul
May 1, 1988·The American Journal of Physiology·S VilaróT Olivecrona
Aug 1, 1985·European Journal of Clinical Investigation·E PerssonL Hagenfeldt
Apr 18, 1970·Lancet·V A Kurien, M F Oliver
Jan 1, 1980·Annual Review of Biochemistry·P Nilsson-EhleM C Schotz
Nov 1, 1994·Scandinavian Journal of Clinical and Laboratory Investigation·M ArnadottirP Nilsson-Ehle
Oct 1, 1993·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·O ChevreuilT Olivecrona

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Citations

Aug 13, 2002·Current Opinion in Hematology·Alexander S Gallus, Douglas W Coghlan
May 20, 2000·Biotechnology & Genetic Engineering Reviews·A Ebringerová, Z Hromádková

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