The synthetic synergistic cinnamon oil CIN-102 is active against Madurella mycetomatis, the most common causative agent of mycetoma.

PLoS Neglected Tropical Diseases
Mickey KoningsWendy W J van de Sande

Abstract

Mycetoma is a devastating neglected tropical infection of the subcutaneous tissue and most commonly caused by the fungus Madurella mycetomatis. Treatment of mycetoma consists of a combination of a long term antifungal treatment with itraconazole and surgery. However, treatment is associated with low success rates. Therefore, there is a need to identify novel treatments for mycetoma. CIN-102 is a synthetic partial copy of cinnamon oils with activity against many pathogenic bacteria and fungi. In this study we determined the in vitro activity of CIN-102 against 21 M. mycetomatis isolates and its in vivo efficacy in a M. mycetomatis infected Galleria mellonella larval model. In vitro, CIN-102 was active against M. mycetomatis with MICs ranging from 32 μg/mL to 512 μg/mL. 128 μg/mL was needed to inhibit the growth in 50% of tested isolates. In vivo, concentrations below the MIC of 40 mg/kg and 80 mg/kg CIN-102 prolonged larval survival, but higher concentrations of CIN-102 did not.

References

Oct 9, 1999·Clinical Microbiology Reviews·M M Cowan
Feb 18, 2003·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·A T PeanaM D L Moretti
Feb 28, 2007·The Journal of Antimicrobial Chemotherapy·Wendy W J van de SandeAlex van Belkum
Jun 25, 2008·Proceedings of the National Academy of Sciences of the United States of America·Jürg GertschAndreas Zimmer
Aug 3, 2012·Transactions of the Royal Society of Tropical Medicine and Hygiene·Hagir A M ZeinManar E Abdel-Rahman
Nov 19, 2013·PLoS Neglected Tropical Diseases·Wendy W J van de Sande
Dec 1, 2004·Drug Discovery Today. Technologies·Christopher A Lipinski
Oct 14, 2014·European Journal of Histochemistry : EJH·F PerdoniE Borghi
Oct 21, 2014·PLoS Neglected Tropical Diseases·Oliverio WelshAhmed Hassan Fahal
Nov 5, 2014·Journal of Advanced Pharmaceutical Technology & Research·Chinjarernpan PanneeLimpanasithikul Wacharee
Mar 15, 2015·PLoS Neglected Tropical Diseases·Hassabelrasoul ElfadilWendy van de Sande
Jul 8, 2015·The British Journal of Dermatology·W W J van de SandeI Bakker-Woudenberg
Jul 15, 2015·PLoS Neglected Tropical Diseases·Wendy KloezenWendy W J van de Sande
Jul 26, 2015·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·M S Nieto-BobadillaC Neut
Dec 7, 2016·International Journal of Molecular Medicine·Young-Hee Jin, Soo-A Kim
Mar 28, 2017·Tropical Medicine & International Health : TM & IH·Kimberly EadieWendy van de Sande
Nov 4, 2017·Pharmaceuticals·Filomena NazzaroVincenzo De Feo
Sep 19, 2019·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Fei HuZhao-Jun Wei
Feb 20, 2020·Scientific Reports·Adam F FeyaertsPatrick Van Dijck

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