The synthetic toxin biliatresone causes biliary atresia in mice.

Laboratory Investigation; a Journal of Technical Methods and Pathology
Yifan YangRui Dong

Abstract

Exposure to environmental toxins may be responsible for biliary atresia. The focus of this study was to investigate the effect of biliatresone on the development of the hepatobiliary system in mice. We successfully synthesized biliatresone with a purity of 98% and confirmed its biliary toxicity. Exposure to high doses of biliatresone caused abortion or death in pregnant mice. Neonatal mice injected with biliatresone developed clinical signs of biliary obstruction, and dysplasia or the absence of extrahepatic biliary tract lumen, which confirmed the occurrence of biliary atresia. In the portal tract of biliary atresia mice, signs of infiltration of inflammatory cells and liver fibrosis were observed. The signature of extrahepatic biliary gene expression in these mice mainly involved the cell adhesion process, and hepatic RNA-seq was highly linked to transcriptional evidence of oxidative stress. When compared with the control group, hepatic glutathione levels were markedly reduced after biliatresone injection. Taken together, these data confirm that biliatresone causes severe developmental abnormalities of the hepatobiliary system in mice. Furthermore, decreased levels of glutathione may play a mechanistic role in the pathogenesi...Continue Reading

References

Jun 1, 1991·Gastroenterology·S N Lichtman, R B Sartor
Jan 1, 1990·Australian Veterinary Journal·P HarperD B Unger
Jun 10, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·K L TylerW R Brown
May 7, 2004·Pediatric Research·Cara L MackStephen D Miller
Nov 24, 2006·Journal of Virology·Steven R AllenGregory M Tiao
Jun 19, 2008·European Journal of Pediatrics·Stefan RauschenfelsClaus Petersen
Feb 26, 2009·Expert Reviews in Molecular Medicine·Shannon S GlaserGianfranco Alpini
Apr 29, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Heping YangShelly C Lu
May 14, 2009·The Journal of Clinical Investigation·Zhaoyu LiKlaus H Kaestner
Feb 11, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Heping YangShelly C Lu
Apr 2, 2010·American Journal of Medical Genetics. Part a·Melissa Leyva-VegaNancy B Spinner
May 13, 2010·Human Molecular Genetics·Maria-Mercè Garcia-BarcelóPaul Kwong-Hang Tam
Jul 18, 2012·Seminars in Pediatric Surgery·Mark Davenport
Jul 18, 2012·Seminars in Pediatric Surgery·Claus Petersen
Sep 4, 2012·The Journal of Biological Chemistry·Komal RamaniShelly C Lu
Sep 22, 2012·Biochimica Et Biophysica Acta·Shelly C Lu
Feb 12, 2013·Seminars in Liver Disease·Cara L MackRonald J Sokol
Jun 12, 2013·Journal of Pediatric Gastroenterology and Nutrition·Małgorzata RurarzJoanna Pawłowska
Jun 27, 2013·Wiley Interdisciplinary Reviews. Developmental Biology·Yiwei Zong, Ben Z Stanger
Aug 31, 2013·Orphanet Journal of Rare Diseases·Claus Petersen, Mark Davenport
Feb 5, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Kazuhiko BesshoJorge A Bezerra
Dec 3, 2014·Biochimica Et Biophysica Acta·Zhi-Wei YeKenneth D Tew
May 8, 2015·Science Translational Medicine·Kristin LorentMichael Pack
Apr 16, 2016·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Orith Waisbourd-ZinmanRebecca G Wells
Apr 23, 2016·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Xiao ZhaoMichael Pack
Nov 24, 2017·Science Translational Medicine·Chatmanee LertudomphonwanitJorge A Bezerra
Jan 20, 2018·ACS Medicinal Chemistry Letters·Michelle A EstradaJeffrey D Winkler
Oct 13, 2019·Pediatrics·Jingying JiangShan Zheng

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Datasets Mentioned

BETA
PRJNA597175

Methods Mentioned

BETA
Assay
RNA-seq
dissection

Software Mentioned

GraphPad Prism
Cuffdiff

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