PMID: 25790696Jan 1, 2014Paper

The system of hemostasis in patients with diabetic foot syndrome undergoing surgical treatment

Klinicheskaia meditsina
Iu G ShapkinA V Khoroshkevich

Abstract

Characteristics of hemostasis system were studied in 185 patients with diabetic foot syndrome undergoing surgical treatment. Disturbances of procoagulative activity persisted within days 1 and 5 after surgery in patients with complicated forms of DFS due to enhanced formation of blood and tissue prothrombinase; simultaneously, the formerly increased fibrinogen level decreased by virtue of intravascular blood coagulation. The activity of natural anticoagulants (antithrombin 111, proteins C andS) continued to be low as a result of their utilization to activate coagulation processes. Resistance of Va factor to activated C protein remained as high as preoperatively. XIIa-Hageman-dependentfJibrinolysis was suppressed and showed no tendency toward recovery.

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