PMID: 15248626Jul 14, 2004Paper

The systemic absorption and disposition of levobupivacaine 0.5% after epidural administration in surgical patients: a stable-isotope study

European Journal of Anaesthesiology
Mischa J G SimonA G Burm

Abstract

Absorption and disposition kinetics can be studied with a stable-isotope method. The aim of this study was to validate a stable-isotope method for levobupivacaine and to derive the relevant pharmacokinetics after epidural administration. Eight volunteers (18-32 yr) received approximately 23 mg of both levobupivacaine and deuterium-labelled levobupivacaine simultaneously by intravenous infusion. Venous blood samples were taken for 8 h. Fifteen patients (23-85 yr) received 19 mL levobupivacaine 0.5% (including a 3 mL test dose) epidurally and, 25 min later, approximately 25 mg deuterium-labelled levobupivacaine (D3-levobupivacaine) intravenously. Arterial blood samples were collected for 24 h. Plasma concentrations were determined using liquid chromatography-mass spectrometry. Plasma concentration-time data were analysed by compartmental and non-compartmental analysis. Based on the ratio of the normalized areas under the curve of unlabelled and deuterium-labelled levobupivacaine in volunteers, as determined by both compartmental (mean ratio: 1.02, 90% CI: 1.00-1.04) and non-compartmental analysis (mean ratio: 1.02, 90% CI: 1.00-1.03) the two formulations were considered equivalent. In surgical patients the elimination half-life (...Continue Reading

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Citations

Jan 29, 2011·Regional Anesthesia and Pain Medicine·Charles W BuffingtonElisabet U M Blix
Apr 18, 2014·Indian Journal of Pharmacology·Hanene EljebariAnis Klouz
Aug 27, 2010·Expert Opinion on Drug Metabolism & Toxicology·Laurence E Mather
Nov 22, 2012·Paediatric Anaesthesia·George A ChalkiadisBrian J Anderson
Apr 27, 2010·Acta Anaesthesiologica Scandinavica·M AllegriM Regazzi
Oct 6, 2010·Regional Anesthesia and Pain Medicine·Charles W Buffington, Elisabet U M Blix
Sep 25, 2008·Anesthesiology·Erik OlofsenAlbert Dahan

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