PMID: 2501396Jul 1, 1989Paper

The systemic administration of gamma interferon inhibits collagen synthesis and acute inflammation in a murine skin wounding model

The Journal of Investigative Dermatology
R D GransteinE P Amento

Abstract

The ability of gamma interferon (IFN-gamma) to affect cutaneous collagen synthesis in vivo was examined in a murine wounding model. Reproducible areas of full-thickness skin necrosis were produced by argon laser radiation. Mice received recombinant murine IFN-gamma (rMuIFN-gamma) (8.7 X 10(3) units/hr) over 14 d via osmotic pumps implanted subcutaneously or intraperitoneally. At 14 and 21 d after wounding, there was less fibrous tissue in healing scars of treated animals as determined by light and transmission electron microscopy. Associated with the decrease in connective tissue was an increase in the acid mucopolysaccharide content of healing scars, which was largely hyaluronate. Quantitative image analysis of electron micrographs confirmed that less collagen was present in healing scars of animals receiving rMuIFN-gamma. The mean cross-sectional area of collagen fibers was smaller in specimens from treated mice, but no difference was seen in the size of collagen fibrils. The time required to obtain full skin closure was also delayed 23%-27% in treated animals. Using this injury model, we also found that rMuIFN-gamma significantly reduced the degree of perilesional erythema surrounding the laser injury sites and, in the first...Continue Reading

References

Dec 1, 1979·The Journal of Experimental Medicine·S A JimenezJ Rosenbloom
Oct 1, 1986·Biochemical Medicine and Metabolic Biology·S N GiriB J Marafino
Apr 1, 1987·The Journal of Clinical Investigation·R D GransteinE P Amento
Jan 1, 1987·Lasers in Surgery and Medicine·S L Jacques, S A Prahl
Sep 1, 1984·The Journal of Clinical Investigation·S A JimenezJ Rosenbloom
Aug 30, 1984·Biochemical and Biophysical Research Communications·J RosenbloomS A Jimenez
Apr 1, 1981·Journal of the American Academy of Dermatology·J C MurrayS R Pinnell
Jun 1, 1982·Journal of Cellular Physiology·T I KorotzerP S Rabinovitch

❮ Previous
Next ❯

Citations

Jan 1, 1995·Scandinavian Journal of Rheumatology. Supplement·R HallmannK Von der Mark
Oct 6, 1997·Proceedings of the National Academy of Sciences of the United States of America·Z ShiD C Rockey
Nov 15, 2000·Journal of Dental Research·A M CornelissenA M Kuijpers-Jagtman
Jan 1, 1991·Rheumatology International·L S Wilkinson, J C Edwards
Nov 9, 2000·The British Journal of Dermatology·T J Ryan
Feb 21, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Annalisa GrimaldiDaniela Negrini
Jan 19, 2006·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Brian BermanKeyvan Nouri
May 1, 2008·The Annals of Otology, Rhinology, and Laryngology·Xinhong LimNathan V Welham
Jun 5, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yang HuLionel B Ivashkiv
Jan 24, 2014·Advances in Pharmacological Sciences·Ashish Subhash BagadAmit Agarwal
Jun 1, 1990·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·A VigneryM H Shepard
Jun 1, 1997·Experimental Dermatology·J B PetriK Herrmann
Sep 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·D C RockeyS L Friedman
Jul 1, 1991·Journal of Neuroscience Research·R P HartG M Jonakait
Sep 25, 2002·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·A M H CornelissenA M Kuijpers-Jagtman
Jan 22, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yuko IshidaNaofumi Mukaida
Apr 17, 2004·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Mark A Carlson, Michael T Longaker
Jan 12, 2007·The Annals of Otology, Rhinology, and Laryngology·Xinhong LimDiane M Bless
Jun 11, 2010·Journal of Biomaterials Science. Polymer Edition·Josna JosephP V Mohanan
Dec 1, 1993·The American Review of Respiratory Disease·R A RosielloE P Amento
May 21, 2013·Journal of Biomaterials Science. Polymer Edition·Josna Joseph, Mira Mohanty
May 9, 2013·Clinical & Developmental Immunology·Michael J GoughMarka Crittenden
Apr 1, 1992·American Journal of Respiratory Cell and Molecular Biology·A AkamineA S Narayanan
Jan 15, 1993·American Journal of Medical Genetics·J L SlackP Bornstein
Oct 1, 2019·The Journal of Investigative Dermatology·Ana TellecheaAristidis Veves
Sep 1, 1999·The Journal of Investigative Dermatology·H KämpferS Frank
Dec 1, 1990·The Journal of Investigative Dermatology·R D GransteinE P Amento
Aug 17, 2005·Cytokine·Donna BryanRobin Thorpe

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.