The systemic control of circadian gene expression

Diabetes, Obesity & Metabolism
Alan GerberUeli Schibler

Abstract

The mammalian circadian timing system consists of a central pacemaker in the brain's suprachiasmatic nucleus (SCN) and subsidiary oscillators in nearly all body cells. The SCN clock, which is adjusted to geophysical time by the photoperiod, synchronizes peripheral clocks through a wide variety of systemic cues. The latter include signals depending on feeding cycles, glucocorticoid hormones, rhythmic blood-borne signals eliciting daily changes in actin dynamics and serum response factor (SRF) activity, and sensors of body temperature rhythms, such as heat shock transcription factors and the cold-inducible RNA-binding protein CIRP. To study these systemic signalling pathways, we designed and engineered a novel, highly photosensitive apparatus, dubbed RT-Biolumicorder. This device enables us to record circadian luciferase reporter gene expression in the liver and other organs of freely moving mice over months in real time. Owing to the multitude of systemic signalling pathway involved in the phase resetting of peripheral clocks the disruption of any particular one has only minor effects on the steady state phase of circadian gene expression in organs such as the liver. Nonetheless, the implication of specific pathways in the synch...Continue Reading

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Citations

May 6, 2016·Cellular and Molecular Life Sciences : CMLS·Xinzhou ZhuSven Wellmann
Dec 23, 2017·Nature Communications·Hsu-Wen ChaoHitoshi Okamura
Jun 6, 2018·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Marco Preußner, Florian Heyd
Oct 19, 2017·Cold Spring Harbor Perspectives in Biology·Paola TogniniPaolo Sassone-Corsi
Oct 28, 2019·Expert Review of Gastroenterology & Hepatology·Yu JiYuchuan Ding
Mar 18, 2020·PLoS Computational Biology·David Laloum, Marc Robinson-Rechavi
Sep 20, 2019·International Journal of Molecular Sciences·Nikolai GenovGianluigi Mazzoccoli
May 30, 2019·Frontiers in Physiology·Dongmei ShiZhijun Bao
Nov 4, 2020·EMBO Reports·Alexander NeumannMarco Preußner

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