The systemic haemodynamic and cerebral autoregulatory effects of bendrofluazide in the subacute post-stroke period

Journal of Hypertension
Penelope J EamesJohn F Potter

Abstract

Little data exist on the efficacy in terms of blood pressure reduction or outcome measures for the various antihypertensive agents in patients post-stroke. In this study the effects of bendrofluazide on blood pressure levels and variability, dynamic cerebral autoregulation and cardiac baroreceptor sensitivity were assessed in the sub-acute stroke period. A total of 36 hypertensive ischaemic stroke patients were randomized to oral bendrofluazide 2.5 mg daily or matching placebo starting 10 days post-ictus and continued for 28 days. A total of 12 hypertensive controls were similarly randomized in a double-blind, crossover study, each limb being of 28 days duration. Cerebral blood flow velocity, non-invasive beat-to-beat blood pressure levels, electrocardiograms (ECGs) and transcutaneous carbon dioxide levels were measured before and at the end of each treatment period in stroke and control subjects. Casual blood pressure levels were not significantly reduced in stroke patients with bendrofluazide, but in the placebo group levels increased by 13 +/- 13/6 +/- 7 mmHg (P < 0.001) at study termination. In the control group, casual systolic blood pressure fell during active treatment by 12 +/- 16 mmHg (P < 0.03) compared with placebo. ...Continue Reading

References

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Aug 29, 2003·American Journal of Hypertension·Penelope J EamesJohn F Potter
Dec 30, 2003·Age and Ageing·Thompson G Robinson, John F Potter

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Citations

Jun 1, 2005·Discovery Medicine·James J Wang
Aug 13, 2010·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Tomomi NakamuraShinichiro Uchiyama
Jul 26, 2006·Pharmacotherapy·Robert L Talbert
Nov 29, 2007·Cardiovascular Engineering·Ronney B Panerai
May 14, 2005·Expert Review of Cardiovascular Therapy·Penelope J V EamesThompson G Robinson
Jan 22, 2005·Journal of Hypertension·UNKNOWN COSSACS Trial Group
Mar 27, 2021·Physiological Reviews·Jurgen A H R ClaassenFrank M Faraci
Nov 6, 2021·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Osian LlwydMartin Müller

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