The systemic nature of mustard lung: Comparison with COPD patients

Interdisciplinary Toxicology
Alireza ShahriaryHossein Rahmani

Abstract

Sulphur mustard (SM) is a powerful blister-causing alkylating chemical warfare agent used by Iraqi forces against Iran. One of the known complications of mustard gas inhalation is mustard lung which is discussed as a phenotype of chronic obstructive pulmonary disease (COPD). In this complication, there are clinical symptoms close to COPD with common etiologies, such as in smokers. Based on information gradually obtained by conducting the studies on mustard lung patients, systemic symptoms along with pulmonary disorders have attracted the attention of researchers. Changes in serum levels of inflammatory markers, such as C-reactive protein (CRP), tumor necrosis factor alpha (TNF-α), nuclear factor κB (NF-κB), matrix metalloproteinases (MMPs), interleukin (IL), chemokines, selectins, immunoglobulins, and signs of imbalance in oxidant-antioxidant system at serum level, present the systemic changes in these patients. In addition to these, reports of extra-pulmonary complications, such as osteoporosis and cardiovascular disease are also presented. In this study, the chance of developing the systemic nature of this lung disease have been followed on using the comparative study of changes in the mentioned markers in mustard lung and CO...Continue Reading

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Citations

Jul 17, 2019·Phytotherapy Research : PTR·Fahimeh Haghighatdoost, Mitra Hariri
Oct 29, 2020·Signal Transduction and Targeted Therapy·Cuixue WangHai Tian
May 1, 2021·Diseases·Alejandro RomeroAntonio Juberias
Jun 8, 2021·Journal of Clinical Laboratory Analysis·Yahui ShenGuixian Song

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Methods Mentioned

BETA
Coronary artery bypass

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