The systemic vasodilatory action of protamine: is it inhibited or mediated by heparin?

Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie
A Ordoñez FernandezJ Lopez Hidalgo

Abstract

The administration of protamine to neutralize the circulating heparin is common practice in cardiovascular surgery. The use of this drug is sometimes associated with hemodynamic alterations of varying degree and intensity (systemic hypotension, pulmonary hypertension and even cardiogenic shock). An intrinsic action of protamine has been suggested to be the cause of these vascular reactions. This action is blocked when protamine forms a complex with heparin, although in other cases it appears that the heparin-protamine complex is the factor responsible for these hemodynamic alterations. The aim of this experimental study was to characterize the vasodilatory action of protamine on the systemic circulation, determining whether or not it is dose-dependent; to analyze the role of endothelium; and to evaluate whether this vasodilatory effect is modified by the presence of heparin. The abdominal aorta was dissected from eight New Zealand rabbits and then sectioned into vascular rings for study in an organ chamber. Mechanical disruption of endothelium was performed on some rings (n = 14). Once submaximal contraction was reached (ClK 80 mM), protamine sulfate with a final concentration in the organ chamber of 80-400 micrograms/ml was ad...Continue Reading

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Citations

Jul 11, 2000·Molecular Biology of the Cell·P Koulen, B E Ehrlich
Sep 15, 2015·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Michael K PugsleyMichael J Curtis
Sep 12, 2014·American Journal of Physiology. Renal Physiology·Kristinn SverrissonBengt Rippe

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