The T-Cell Immune Response against Kaposi's Sarcoma-Associated Herpesvirus.

Advances in Virology
Rebecca C RobeyFrances M Gotch

Abstract

Kaposi's sarcoma-associated herpesvirus (KSHV) is the aetiological agent of Kaposi's sarcoma (KS), the most frequently arising malignancy in individuals with untreated HIV/AIDS. There are several lines of evidence to indicate that Kaposi's sarcoma oncogenesis is associated with loss of T-cell-mediated control of KSHV-infected cells. KSHV can establish life-long asymptomatic infection in immune-competent individuals. However, when T-cell immune control declines, for example, through AIDS or treatment with immunosuppressive drugs, both the prevalence of KSHV infection and the incidence of KS in KSHV carriers dramatically increase. Moreover, a dramatic and spontaneous improvement in KS is frequently seen when immunity is restored, for example, through antiretroviral therapy or the cessation of iatrogenic drugs. In this paper we describe the current state of knowledge on the T-cell immune responses against KSHV.

References

Aug 1, 1996·Nature Medicine·M F CallanA J McMichael
Apr 2, 1998·The New England Journal of Medicine·J N MartinD H Kedes
Jul 8, 1998·Proceedings of the National Academy of Sciences of the United States of America·P S GillP A Jones
Jun 11, 1999·Journal of Virology·M OsmanF Gotch
Feb 9, 2000·The Journal of Experimental Medicine·E CesarmanM C Gershengorn
May 9, 2000·Microbes and Infection·J DéchanetJ F Moreau
Jun 26, 2001·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·B EnsoliP Monini
Mar 12, 2002·JAMA : the Journal of the American Medical Association·Massimo AndreoniGiovanni Rezza
Apr 3, 2002·Nature Medicine·Victor AppaySarah L Rowland-Jones
May 30, 2002·Nature Reviews. Immunology·Simon R Carding, Paul J Egan
Jun 5, 2002·Nature Reviews. Cancer·Chris Boshoff, Robin Weiss
Jul 9, 2002·Immunology·Fabiola MichelettiRiccardo Gavioli
Dec 5, 2002·Trends in Immunology·Debbie van BaarleFrank Miedema
Jun 10, 2003·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Wolfgang HladikEve M Lackritz
Aug 16, 2003·Transfusion·P E PellettUNKNOWN Retrovirus Epidemiology Donor Study
Mar 23, 2004·Annual Review of Immunology·Federica SallustoAntonio Lanzavecchia
Dec 14, 2004·Science·Casper PaludanChristian Münz
Dec 13, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Elise LandaisElisabeth Houssaint
Jan 6, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Eliana RibechiniRiccardo Gavioli
Sep 5, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Graham S TaylorAlan B Rickinson
Sep 23, 2006·The Journal of Infectious Diseases·Amelie GuihotGuislaine Carcelain
Nov 15, 2006·Autophagy·Graham S Taylor, Alan B Rickinson
Jul 12, 2007·Journal of the National Cancer Institute·Renan DuprezAntoine Gessain
Feb 23, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Serge BarcyLawrence Corey
Jul 5, 2008·The Lancet Oncology·D Max ParkinHenry Wabinga

❮ Previous
Next ❯

Citations

Nov 7, 2014·Viruses·Veenu Minhas, Charles Wood
Sep 16, 2014·Frontiers in Microbiology·Diana M CampbellCharles R Rinaldo
Jul 17, 2012·Current Opinion in Virology·Ting-Ting WuRen Sun
Mar 7, 2017·Journal of Clinical Pharmacy and Therapeutics·D OlivoF Ursini
Feb 13, 2019·International Immunology·Kelly G PaulsonIsaac Brownell
Jul 29, 2015·Clinical Reviews in Allergy & Immunology·Gwilym J WebbPeter J L Lane
May 6, 2017·Frontiers in Microbiology·Kawalpreet K Aneja, Yan Yuan
Jan 26, 2017·AIDS Research and Human Retroviruses·Lauren M LeponeCharles R Rinaldo
Mar 3, 2020·Frontiers in Immunology·Grant Broussard, Blossom Damania
Dec 10, 2020·Journal of Immunology Research·Owen Ngalamika, Sody Munsaka
Apr 13, 2021·Frontiers in Cellular and Infection Microbiology·Christian Münz

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy

Related Concepts

Related Feeds

HIV/AIDS-Related Malignancies

HIV/AIDS infection increases the risk of non-communicable diseases common in the aged including HIV/AIDS-related malignancies. Discover the latest research in HIV/AIDS-related malignancies.