PMID: 9159147May 27, 1997Paper

The T cell receptor repertoire of intestinal intraepithelial gammadelta T lymphocytes is influenced by genes linked to the major histocompatibility complex and to the T cell receptor loci

Proceedings of the National Academy of Sciences of the United States of America
P PereiraS Tonegawa

Abstract

Most of the gammadelta T cells in the intestinal epithelium of normal mice use the Vgamma1 or the Vgamma7 gene segments. However, the relative proportions of gammadelta intraepithelial lymphocytes expressing either the Vgamma1 or the Vgamma7 chain vary among different strains of mice whereas they are quite constant between different individuals of the same strain, suggesting that genetic factors, rather than environmental factors, are responsible for the observed differences. To analyze the genetic factors influencing the representation of different gammadelta T cell subsets in the intestinal epithelium, we used available anti-T cell antigen receptor (TCR) V region-specific mAbs against Vgamma1, Vgamma4, Vgamma7, and Vdelta4 to examine the TCR repertoire of intraepithelial gammadelta lymphocytes in a set of (C57BL/6 x DBA/2) recombinant inbred strains. Our results show that the representation of different Vgamma and Vdelta gene products among gammadelta intestinal intraepithelial lymphocytes is under a complex genetic control with a marked influence by genes closely linked to the TCRgamma, TCRdelta, and major histocompatibility complex loci.

References

Mar 1, 1978·The Journal of Experimental Medicine·R M ZinkernagelJ Klein
Jan 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·I CorreaD Raulet
Jan 1, 1990·The Journal of Experimental Medicine·A M PullenP Marrack
Jan 1, 1989·Cold Spring Harbor Symposia on Quantitative Biology·B A HouldenJ A Bluestone
Jul 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·S ItoharaS Tonegawa
Jun 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·S BuusH M Grey
Apr 24, 1987·Cell·J W KapplerP Marrack
Jul 1, 1993·The Journal of Experimental Medicine·G LeclercqJ P Allison
Sep 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·H IshikawaS Tonegawa

❮ Previous
Next ❯

Citations

Mar 4, 2011·Proceedings of the National Academy of Sciences of the United States of America·Anna BasAdrian C Hayday
Feb 13, 2007·Immunological Reviews·Benedita Rocha
Jan 28, 2004·Nutritional Neuroscience·Byron C JonesJohn L Beard
Aug 17, 2016·Scientific Reports·Cristina Lebrero-Fernández, Anna Bas-Forsberg
May 31, 2017·Immunology·Min Cheng, Shilian Hu
Oct 21, 2015·Nature Immunology·Dale I GodfreyD Branch Moody
May 4, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Byron C JonesChristopher J Earley
Feb 4, 2012·Microbiology and Immunology·Kensuke Shibata
Jun 22, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·V Azuara, P Pereira
Mar 11, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sally HuberMark Exley
Oct 18, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·S A HuberR L O'Brien
Sep 24, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kalliopi GrigoriadouPablo Pereira

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.