PMID: 11922439Apr 2, 2002Paper

The T wave as a marker of dispersion of ventricular repolarization in premature infants before and while on treatment with the I(Kr) channel blocker cisapride

Cardiology in the Young
Avram BenatarY Vandenplas

Abstract

Measurement of electrocardiographic intervals to assess dispersion in ventricular repolarization may be helpful in the assessment of the risk of ventricular arrhythmia. We measured QTc, QT dispersion, and T wave intervals in premature infants before and while on treatment with the I(Kr) blocker cisapride as markers for dispersion in ventricular repolarization. We enrolled 15 non-ventilated premature infants with a mean gestational age of 30.5 weeks, ranging from 26.5 to 33.5 weeks, and mean postnatal age of 24 days, with a range from 5 to 51 days. A digital 12 lead electrocardiogram was recorded prior to and 3 days after administering cisapride at a dose of 0.8 mg/kg/day. Serum electrolytes were simultaneously measured. Electrocardiographic measurements before and after included: QT, QTc Bazett, QT dispersion, R-R, T wave interval peak to end, T wave interval peak to end/onset Q to T wave peak, T wave axis, T wave maximum voltage and QRS-T angle. A paired t test and analysis of variance was used to compare the variables before and during treatment. The QTc, T wave interval peak to end and the ratio T wave interval peak to end/onset Q to T peak increased significantly following treatment with cisapride. Results expressed as befo...Continue Reading

Citations

May 19, 2010·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·A CorriasB Rodriguez
Jul 24, 2003·Journal of Cardiovascular Electrophysiology·Gan-Xin Yan, Jack Martin
Aug 21, 2008·Anesthesia and Analgesia·Helen V Hume-SmithSimon D Whyte
Jul 31, 2014·Anesthesia and Analgesia·Simon D WhyteShubhayan Sanatani

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