The T244I variant of the interleukin-7 receptor-alpha gene and multiple sclerosis

Tissue Antigens
Antonio AlcinaFuencisla Matesanz

Abstract

Several but not all studies have provided evidence for the association between multiple sclerosis (MS) and the T244I variant of the interleukin-7 receptor-alpha gene (IL7RA), rs6897932. We performed a new replication case-control study in 599 MS patients and 594 healthy controls, all Caucasians from the south of Spain. The genotype and allele frequencies differed between MS cases and controls. The IL7RA rs6897932 C allele and the CC genotype were found to be factors for disease susceptibility [per allele odds ratio (OR) 1.32, 95% CI 1.1-1.6, P=0.0031; per CC genotype vs TT + TC genotypes, OR 1.5, 95% CI 1.18-1.87, P=0.0007]. The combined data analysis included 3324 cases and 5032 controls of Europeans and Americans of European origin resulting in stronger association with similar OR (P=1.9 x 10E-9). These findings in our sample support previous reported association studies between IL7RA rs6897932 and MS.

References

Mar 1, 1983·Annals of Neurology·C M PoserW W Tourtellotte
Aug 1, 1996·Nature Genetics·G C EbersN Risch
Aug 3, 2002·Nature Reviews. Immunology·Stephen C Jameson
Jan 30, 2004·Lancet Neurology·David A DymentA Dessa Sadovnick
May 25, 2004·Brain : a Journal of Neurology·A BartonJ Worthington
Feb 22, 2005·Lancet Neurology·Donald H Gilden
Apr 26, 2005·Lancet Neurology·Diego Franciotta, Francesco Lolli
Aug 3, 2005·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·D R BoothUNKNOWN Southern MS Genetics Consortium
Aug 5, 2005·American Journal of Human Genetics·Stephen SawcerUNKNOWN International Multiple Sclerosis Genetics Consortium
Apr 6, 2006·PLoS Genetics·Janna SaarelaLeena Peltonen
Apr 11, 2007·Journal of Neurology·Fuencisla MatesanzAntonio Alcina
Jun 8, 2007·Nature·UNKNOWN NCI-NHGRI Working Group on Replication in Association StudiesFrancis S Collins
Jul 31, 2007·The New England Journal of Medicine·UNKNOWN International Multiple Sclerosis Genetics ConsortiumStephen L Hauser
Jul 31, 2007·Nature Genetics·Simon G GregoryUNKNOWN Multiple Sclerosis Genetics Group
Nov 23, 2007·The New England Journal of Medicine·Sreeram V RamagopalanGeorge C Ebers
Feb 15, 2008·The New England Journal of Medicine·Catherine O'DohertyKoen Vandenbroeck

❮ Previous
Next ❯

Citations

Oct 30, 2013·Journal of Molecular Neuroscience : MN·Leena IbayyanMamoun Ahram
Nov 18, 2008·Human Molecular Genetics·Sergio E BaranziniJorge R Oksenberg
Nov 4, 2011·Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række·Hanne F HarboAnne Spurkland
Dec 31, 2010·Immunological Investigations·Moones HeidariMohammad-Ali Sahraian
Mar 20, 2012·Seminars in Immunology·Renata I MazzucchelliScott K Durum
Mar 29, 2011·Neurologic Clinics·Joseph P McElroy, Jorge R Oksenberg
May 11, 2010·Molecular and Cellular Probes·Sabine Hoffjan, Denis A Akkad
Feb 24, 2009·Journal of Autoimmunity·D A AkkadJ T Epplen
Jul 28, 2016·Multiple Sclerosis and Related Disorders·Soheil Tavakolpour
May 18, 2016·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Song WuMei-Guo Sun
May 6, 2011·Multiple Sclerosis : Clinical and Laboratory Research·M H SombekkeJ Killestein
Mar 3, 2010·Multiple Sclerosis : Clinical and Laboratory Research·Aleksandra StankovićMaja Zivković
Dec 18, 2013·Molecular Medicine Reports·Jason Yongha KimHyoung Doo Shin
Dec 17, 2010·Molecular Biology Reports·Ruijie ZhangXia Li
Feb 18, 2020·Journal of Neuroimmunology·Mohammad Hossein Sahami-FardAkram Nezhadi
Mar 18, 2021·ImmunoTargets and Therapy·Priscila O BarrosJonathan B Angel

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.