The tachykinin receptor 3 is associated with alcohol and cocaine dependence.

Alcoholism, Clinical and Experimental Research
Tatiana ForoudHoward J Edenberg

Abstract

A broad region on chromosome 4q was previously linked to the phenotype of alcohol dependence in the Collaborative Study on the Genetics of Alcoholism sample. A strong positional candidate gene was identified within this region: tachykinin receptor 3 gene (TACR3), which encodes tachykinin receptor 3 (NK3R), the receptor for the tachykinin 3 (neurokinin B) peptide. Pharmacological studies have provided evidence that the administration of NK3R agonists attenuates the intake of alcohol and NK3R can also mediate the acute and chronic behavioral effects of cocaine. Thirty SNPs were genotyped throughout TACR3. Family based association analysis was performed in 219 European American families to detect an association with alcohol dependence. Subsequent analyses were performed to evaluate the evidence of association with other definitions of alcohol dependence as well as cocaine dependence. Seven of the 9 SNPs in the 3' region of TACR3 provided significant evidence of association with alcohol dependence (p <or= 0.05). Further analyses suggest that the evidence of association is strongest among those subjects with more severe alcohol dependence (defined by ICD-10) and those with co-morbid cocaine dependence. Haplotype analyses further str...Continue Reading

References

Jun 1, 1979·The British Journal of Addiction to Alcohol and Other Drugs·D W Goodwin
Jan 1, 1991·Archives of General Psychiatry·R W PickensP J Clayton
Jan 1, 1972·Archives of General Psychiatry·J P FeighnerR Munoz
Aug 1, 1981·Archives of General Psychiatry·C R CloningerS Sigvardsson
May 1, 1980·Archives of General Psychiatry·R J CadoretW M Grove
May 1, 1994·The American Journal of Psychiatry·K S KendlerL J Eaves
Jun 23, 1998·American Journal of Human Genetics·J R O'Connell, D E Weeks
Jan 1, 2000·Addiction·M HesselbrockV Hesselbrock
May 29, 2000·American Journal of Human Genetics·E R MartinN L Kaplan
Aug 3, 2000·Alcoholism, Clinical and Experimental Research·T ForoudT Reich
Mar 20, 2001·American Journal of Human Genetics·E R MartinN L Kaplan
Aug 14, 2003·Genetic Epidemiology·Frank Dudbridge
Jul 27, 2004·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Jonathan CovaultHenry R Kranzler
Aug 7, 2004·Bioinformatics·J C BarrettM J Daly
Apr 19, 2005·Alcoholism, Clinical and Experimental Research·Jaakko LappalainenJoel Gelernter
May 3, 2005·The American Journal of Psychiatry·Camila GuindaliniMayana Zatz
Oct 26, 2005·Nature Genetics·Paul I W de BakkerDavid Altshuler
Mar 31, 2006·Human Molecular Genetics·Howard J EdenbergTatiana Foroud
Apr 11, 2006·European Journal of Pharmacology·Maria A De Souza SilvaMarilia Barros
Sep 14, 2007·Alcoholism, Clinical and Experimental Research·Tatiana ForoudHoward J Edenberg

❮ Previous
Next ❯

Citations

Feb 22, 2012·Genome Biology·Tatiana V MorozovaRobert R H Anholt
Jan 19, 2013·Arquivos brasileiros de endocrinologia e metabologia·Cintia TussetAna Claudia Latronico
Jan 8, 2014·Molecular Genetics and Genomics : MGG·Tatiana V MorozovaRobert R H Anholt
Sep 26, 2014·International Journal of Endocrinology·Marco MarinoManuela Simoni
Mar 17, 2010·The Journal of Physiology·Yan-Fang XiaGregory O Hjelmstad
Dec 25, 2010·Annals of the New York Academy of Sciences·Lorraine GunzerathKenneth R Warren
Feb 15, 2011·Alcoholism, Clinical and Experimental Research·Kenneth S KendlerPablo V Gejman
Jun 19, 2009·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Xiaoling XueiHoward J Edenberg
Nov 15, 2013·Alcoholism, Clinical and Experimental Research·Susanne JonssonBo Söderpalm
Mar 6, 2010·Alcoholism, Clinical and Experimental Research·Howard J EdenbergTatiana Foroud
Oct 16, 2012·Drug and Alcohol Dependence·Jonathan L MelamedMarilia Barros
Nov 18, 2014·Current Psychiatry Reports·Priya A Iyer-Eimerbrink, John I Nurnberger
Jun 29, 2010·Journal of Affective Disorders·José Javier Miguel-HidalgoCraig A Stockmeier
Jun 10, 2005·Drug and Alcohol Dependence·Rosa M CrumYa-Fen Chan
Jan 1, 2015·International Scholarly Research Notices·Anthony KarpouzisStavroula Veletza
Aug 17, 2019·Frontiers in Neuroscience·Hana ZoubkováRomana Šlamberová
Feb 17, 2021·The Pharmacogenomics Journal·David BrightMinji Sohn
Sep 25, 2017·Progress in Neuro-psychopharmacology & Biological Psychiatry·Kathleen A Brown-RiceGina L Forster
Sep 15, 2020·ACS Chemical Neuroscience·Wen-Wen ZhangYu-Xia Chu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.