The tale of early hematopoietic cell seeding in the bone marrow niche

Stem Cells and Development
Isaac YanivNadir Askenasy

Abstract

Since introduction of the notion of a "niche" that hosts engraftment and activity of hematopoietic cells, there is a massive effort to discover its structure and decipher its function. Our understanding of the niche is continuously changing with reinterpretation of traditional concepts and apprehension of new insights into the biology of hematopoietic cell homing, seeding, and engraftment. Here we discuss some of the early events in hematopoietic stem cell seeding and engraftment and propose a perspective based on visualization of labeled bone marrow cells in real time in vivo. Primary seeding of hematopoietic cells in the bone marrow niches evolves as a complex and dynamic process; however, it follows discrete topological and chronological patterns. Initial seeding occurs on the endosteal surface of the marrow, which includes heterogeneous niches for primary seeding. Several days after transplantation the endosteal niches become more restrictive, hosting primarily mitotically quiescent cells, and gradual centripetal migration is accompanied by engagement in proliferation and differentiation. The hematopoietic niches evolve as heterogeneous three-dimensional microenvironments that are continuously changing over time.

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Citations

Mar 25, 2009·Cancer Microenvironment : Official Journal of the International Cancer Microenvironment Society·Christophe F ChantrainYves A DeClerck
Jun 10, 2011·Stem Cells and Development·Stanislav FilipDenis English
Dec 29, 2007·Immunological Investigations·Nadir AskenasyDaniel L Farkas
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Aug 8, 2008·Acta Medica (Hradec Králové)·Miroslav HodekStanislav Filip

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