The tale of xenotropic murine leukemia virus-related virus.

The Journal of General Virology
Harriet C T Groom, Kate N Bishop

Abstract

In 2006, a new retrovirus was isolated from prostate cancer patient tissue. Named xenotropic murine leukemia virus-related virus (XMRV), this was potentially the third class of retrovirus to be pathogenic in humans. XMRV made a more dramatic impact on the wider scientific community, and indeed the media, in 2009 when it was reported to be present in a remarkably high proportion of patients with chronic fatigue syndrome as well as a significant, albeit smaller, proportion of healthy controls. The apparent strong link to disease and the fear of a previously unknown retrovirus circulating in the general population lead to a surge in XMRV research. Subsequent studies failed to find an association of XMRV with disease and, in most cases, failed to find the virus in human samples. In 2011, the case against XMRV and human disease strengthened, ending with several decisive publications revealing the origin of the virus and demonstrating contamination of samples. In this review, we outline the passage of research on XMRV and its potential association with disease from its isolation to the present day, where we find ourselves at the end of a turbulent story.

References

Feb 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·J W HartleyW P Rowe
Apr 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·E DeFreitasH Koprowski
Feb 1, 1990·Genetics·W N FrankelJ M Coffin
Jan 1, 1996·Clinical Microbiology Reviews·D N Fredricks, D A Relman
Feb 3, 1999·Proceedings of the National Academy of Sciences of the United States of America·J A Levy
Feb 3, 1999·Proceedings of the National Academy of Sciences of the United States of America·C S TailorD Kabat
Feb 17, 1999·Proceedings of the National Academy of Sciences of the United States of America·J L BattiniA D Miller
Dec 3, 1999·The International Journal of Biochemistry & Cell Biology·S K Ruscetti
Nov 5, 2002·Nature Genetics·Graham CaseyJohn S Witte
Dec 6, 2002·Nature·UNKNOWN Mouse Genome Sequencing ConsortiumEric S Lander
Jan 20, 2007·Proceedings of the National Academy of Sciences of the United States of America·Beihua DongRobert H Silverman
Aug 8, 2007·Cytokine & Growth Factor Reviews·Robert H Silverman
Oct 30, 2007·Journal of Medical Microbiology·Timothy J J Inglis
Mar 7, 2008·Microbiology and Molecular Biology Reviews : MMBR·Cécile VoissetDavid J Griffiths
Sep 27, 2008·Cellular and Molecular Life Sciences : CMLS·C Stocking, C A Kozak
Oct 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Robert SchlabergIla R Singh
Dec 5, 2009·Virology·Ryuta SakumaYasuhiro Ikeda
Jan 13, 2010·PloS One·Otto ErlweinAnthony Cleare
Jan 30, 2010·Virology·Kristin StielerNicole Fischer
Mar 3, 2010·Proceedings of the National Academy of Sciences of the United States of America·Harriet C T GroomKate N Bishop
May 15, 2010·Science·Richard K BurtShimon Slavin
May 29, 2010·Emerging Infectious Diseases·Nicole FischerMartin Aepfelbacher
Jun 26, 2010·BMC Cancer·Margarita L Martinez-FierroAugusto Rojas-Martinez
Aug 4, 2010·Retrovirology·Eric JeziorskiValérie Courgnaud
Aug 14, 2010·PloS One·Marion CornelissenAntoinette C van der Kuyl

❮ Previous
Next ❯

Citations

Apr 13, 2013·International Journal of Cancer. Journal International Du Cancer·Brian Salmons, Walter H Gunzburg
Jul 19, 2012·The FEBS Journal·Krisztina MatúzJózsef Tőzsér
Aug 27, 2016·Science·Khalil EttayebiMary K Estes
Apr 6, 2020·The Medical Journal of Australia·Carolina X Sandler, Andrew R Lloyd
May 24, 2020·Journal of Cosmetic Dermatology·Mohit KumarUttam Kumar Mandal
Aug 3, 2012·The Journal of Physiology·Michael J Joyner
Oct 17, 2017·Virology Journal·Raisa PerzovaBernard Poiesz
Apr 10, 2019·Nature Reviews. Microbiology·Welkin E Johnson

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved