The taming of a transposon: V(D)J recombination and the immune system

Immunological Reviews
Jessica M Jones, M Gellert

Abstract

The genes that encode immunoglobulins and T-cell receptors must be assembled from the multiple variable (V), joining (J), and sometimes diversity (D) gene segments present in the germline loci. This process of V(D)J recombination is the major source of the immense diversity of the immune repertoire of jawed vertebrates. The recombinase that initiates the process, recombination-activating genes 1 (RAG1) and RAG2, belongs to a large family that includes transposases and retroviral integrases. RAG1/2 cleaves the DNA adjacent to the gene segments to be recombined, and the segments are then joined together by DNA repair factors. A decade of biochemical research on RAG1/2 has revealed many similarities to transposition, culminating with the observation that RAG1/2 can carry out transpositional strand transfer. Here, we discuss the parallels between V(D)J recombination and transposition, focusing specifically on the assembly of the recombination nucleoprotein complex, the mechanism of cleavage, the disassembly of post-cleavage complexes, and aberrant reactions carried out by the recombinase that do not result in successful locus rearrangement and may be deleterious to the organism. This work highlights the considerable diversity of tr...Continue Reading

References

Oct 25, 1991·Nucleic Acids Research·S Paillard, F Strauss
Dec 22, 1989·Cell·D G SchatzD Baltimore
Nov 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·R CraigieK Mizuuchi
Dec 23, 1988·Cell·S M LewisM Gellert
Jan 1, 1988·Current Topics in Microbiology and Immunology·M R LieberM Gellert
Apr 14, 1983·Nature·S Tonegawa
Oct 1, 1995·Genes & Development·I LevchenkoT A Baker
Oct 1, 1995·Genes & Development·D A Ramsden, M Gellert
Oct 13, 1995·Science·N L Craig
Jan 1, 1995·Molecular Microbiology·P Polard, M Chandler
Jun 16, 1995·Cell·D C van GentM Gellert
Jan 1, 1994·Pharmacology & Therapeutics·J Kulkosky, A M Skalka
Mar 29, 1994·Proceedings of the National Academy of Sciences of the United States of America·W C Lin, S Desiderio
May 25, 1994·Nucleic Acids Research·M J SadofskyM Gellert
May 25, 1994·Nucleic Acids Research·C A Cuomo, M A Oettinger
Nov 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·D B RothM Gellert
Dec 11, 1993·Nucleic Acids Research·M J SadofskyM Gellert
Jul 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·D P SilverD Baltimore
Jan 1, 1996·Current Topics in Microbiology and Immunology·R Kunze
Apr 19, 1996·Science·E W May, N L Craig
Feb 1, 1996·Current Opinion in Structural Biology·P RiceD R Davies
Jan 1, 1996·Current Topics in Microbiology and Immunology·S DesiderioZ Li
Oct 1, 1996·Nucleic Acids Research·D York, W S Reznikoff
May 15, 1997·The EMBO Journal·D C van GentM Gellert
Aug 1, 1997·Molecular and Cellular Biology·C J McMahanD G Schatz
May 2, 1998·Science·M MelekD C van Gent

❮ Previous
Next ❯

Citations

Dec 14, 2006·Immunogenetics·Marsha R Haynes, Gillian E Wu
Aug 4, 2009·Genetica·Corentin Claeys Bouuaert, Ronald M Chalmers
Dec 15, 2006·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·David H Dreyfus
Dec 12, 2012·Quarterly Reviews of Biophysics·Fred DydaAlison Burgess Hickman
Mar 15, 2008·Proceedings of the National Academy of Sciences of the United States of America·Ludivine SinzelleZoltán Ivics
Apr 15, 2008·Proceedings of the National Academy of Sciences of the United States of America·Ruslan KalendarAlan H Schulman
Dec 1, 2011·The Journal of Biological Chemistry·Jochen GovaertDirk Saerens
Sep 6, 2007·The Journal of Experimental Medicine·John D CurryMark S Schlissel
Dec 4, 2010·Genome Biology and Evolution·Peter A NovickStéphane Boissinot
Feb 22, 2013·Genome Biology and Evolution·Moaine El Baidouri, Olivier Panaud
Feb 3, 2005·Genes & Development·Camil E SayeghCornelis Murre
Dec 17, 2009·Genes & Development·Emad BarsoumStefan U Aström
Jun 2, 2006·Molecular and Cellular Biology·Aleksei N KriatchkoPatrick C Swanson
Apr 10, 2013·Blood·Justin WrayRobert Hromas
Sep 2, 2006·Cell Division·Melissa M Adams, Phillip B Carpenter
Dec 6, 2007·Genome Biology·Lara S Collier, David A Largaespada
Oct 13, 2006·PLoS Genetics·Jianbo ZhangThomas Peterson
Dec 14, 2007·Annual Review of Genetics·Cédric Feschotte, Ellen J Pritham
Sep 6, 2007·Proceedings of the National Academy of Sciences of the United States of America·Michiyo MizuuchiKiyoshi Mizuuchi
Oct 15, 2014·Proceedings of the National Academy of Sciences of the United States of America·Naghmeh RajaeiStefan U Aström
Nov 10, 2015·Critical Reviews in Oncology/hematology·Sridaran Dhivya, Kumpati Premkumar
Jun 13, 2014·The American Naturalist·Tyler A ElliottT Ryan Gregory
Sep 18, 2012·Biochimica Et Biophysica Acta·Benoît Chénais
Dec 1, 2010·DNA Repair·Kevin Hiom
Sep 21, 2010·Seminars in Cancer Biology·Zoltán Ivics, Zsuzsanna Izsvák
Jul 6, 2010·Seminars in Cancer Biology·Dale A RamsdenYeturu V R Reddy
Dec 17, 2009·Seminars in Immunology·Sebastian D Fugmann
Nov 23, 2006·Seminars in Cancer Biology·Fabien Kuttler, Sabine Mai
Aug 6, 2013·Mobile Genetic Elements·Richard G HunterDonald W Pfaff
Apr 8, 2010·Cell·André Nussenzweig, Michel C Nussenzweig
May 21, 2016·Molecular Therapy : the Journal of the American Society of Gene Therapy·Zoltán Ivics
Jul 13, 2016·Evolution; International Journal of Organic Evolution·T Fatima MitterboeckSarah J Adamowicz
Sep 8, 2016·Critical Reviews in Biochemistry and Molecular Biology·James A Shapiro
Apr 25, 2006·Current Problems in Pediatric and Adolescent Health Care·David B LewisE Richard Stiehm
May 4, 2017·Nature Communications·Yoko IkedaOlivier Mathieu
Jan 14, 2010·Critical Reviews in Biochemistry and Molecular Biology·Alison Burgess HickmanFred Dyda
Jul 1, 2006·Nature·Alysson R Muotri, Fred H Gage
Jul 24, 2007·The Journal of Biological Chemistry·Mei TangDonald C Rio

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.