The Taming of the Shrew--Controlling the Morphology of Filamentous Eukaryotic and Prokaryotic Microorganisms

Advances in Biochemical Engineering/biotechnology
Robert WaliskoRainer Krull

Abstract

One of the most sensitive process characteristics in the cultivation of filamentous biological systems is their complex morphology. In submerged cultures, the observed macroscopic morphology of filamentous microorganisms varies from freely dispersed mycelium to dense spherical pellets consisting of a more or less dense, branched and partially intertwined network of hyphae. Recently, the freely dispersed mycelium form has been in high demand for submerged cultivation because this morphology enhances the growth and production of several valuable products. A distinct filamentous morphology and productivity are influenced by the environment and can be controlled by inoculum concentration, spore viability, pH value, cultivation temperature, dissolved oxygen concentration, medium composition, mechanical stress or process mode as well as through the addition of inorganic salts or microparticles, which provides the opportunity to tailor a filamentous morphology. The suitable morphology for a given bioprocess varies depending on the desired product. Therefore, the advantages and disadvantages of each morphological type should be carefully evaluated for every biological system. Because of the high industrial relevance of filamentous micr...Continue Reading

Citations

Feb 24, 2018·Applied Microbiology and Biotechnology·Lukas VeiterChristoph Herwig
Jun 11, 2019·Biotechnology and Bioengineering·Xiulai ChenLiming Liu
Jun 13, 2021·Applied Biochemistry and Biotechnology·Pfariso MaumelaJohann Ferdinand Görgens

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