PMID: 9159219Aug 1, 1996Paper

The tau proteins in neuronal growth and development

Frontiers in Bioscience : a Journal and Virtual Library
R Brandt

Abstract

The neuronal microtubule-associated protein tau has been implicated as having a role in the outgrowth of neural processes and the development of neuronal polarity. In vitro, tau promotes microtubule assembly, stabilizes cellular microtubules, and affects their dynamic behavior. Antisense experiments using cultured neurons provided evidence for an essential role of tau in the development of axons. However, tau knockout mice turned out to be surprisingly healthy and developed neurons which were functionally and structurally almost normal. This raises the question of how essential tau is for neuronal development. In the first part of this paper, data on the function of tau as a microtubule assembly-promoting and stabilizing factor are reviewed. Then, studies investigating the role of tau in the development of neuronal polarity are discussed. In the last part, recent results which provide evidence for a role of tau not directly related to its activity on microtubule assembly are summarized.

Citations

Dec 6, 2008·PLoS Computational Biology·Da-Wei LiShuanghong Huo
Nov 10, 2009·BMC Cell Biology·Hai Jin HeRong Qiao He
Sep 24, 2004·The Journal of Biological Chemistry·Patrizia FanaraMarc K Hellerstein
May 27, 2008·Journal of Neuroscience Research·David GordonRoss Smith
Jul 21, 1999·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·G RamírezR B Maccioni
Sep 15, 2010·Journal of Molecular Neuroscience : MN·Xiao-Li LiXiao-Ping Dong
Oct 8, 2014·The FEBS Journal·Linda A Amos
Oct 20, 2004·Genesis : the Journal of Genetics and Development·Ella Korets-SmithAndras Nagy
May 31, 2017·Molecular Psychiatry·C DioliI Sotiropoulos
May 8, 2020·Neurobiology of Disease·Annis-Rayan BourefisEdor Kabashi
Nov 30, 2004·Neuroscience Letters·Francesca MegiorniMaria Cristina Mazzilli
Dec 13, 2005·Biophysical Journal·Hideyo InouyeDaniel A Kirschner
May 30, 2006·Journal of Biotechnology·Tomohide NodaEiry Kobatake

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