The tax protein from the primate T-cell lymphotropic virus type 3 is expressed in vivo and is functionally related to HTLV-1 Tax rather than HTLV-2 Tax

Oncogene
Sébastien A ChevalierRenaud Mahieux

Abstract

Human T-cell leukemia virus and simian T-cell leukemia virus (STLV) form the primate T-cell lymphotropic viruses group. Human T-cell leukemia virus type 1 and type 2 (HTLV-1 and HTLV-2) encode the Tax viral transactivator (Tax1 and Tax2, respectively). Tax1 possesses an oncogenic potential and is responsible for cell transformation both in vivo and in vitro. We and others have recently discovered the existence of human T-cell lymphotropic virus type 3. However, there is currently no evidence for the presence of a Tax protein in HTLV-3-infected individuals. We show that the serum of an HTLV-3 asymptomatic carrier and the sera of two STLV-3-infected monkeys contain specific anti-Tax3 antibodies. We also show that tax3 mRNA is present in the PBMCs obtained from an STLV-3-infected monkey, demonstrating that Tax3 is expressed in vivo. We further demonstrate that Tax3 intracellular localization is very similar to that of Tax1 and that Tax3 binds to both CBP and p300 coactivators. Using purified Tax3, we show that the protein increases transcription from a 4TxRE G-free cassette plasmid in an in vitro transcription assay. In all cell types tested, including transiently transfected lymphocytes, Tax3 activates its own promoter STLV-3 lon...Continue Reading

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Citations

Jan 6, 2010·AIDS Research and Human Retroviruses·Anish ThomasBernard J Poiesz
Sep 23, 2006·Blood·Jean-Claude TwizereRichard Kettmann
Dec 9, 2009·Expert Review of Anti-infective Therapy·Péter BagossiJózsef Tözsér
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Aug 7, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Philippe Vicente AfonsoPierre-Emmanuel Ceccaldi

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