PMID: 8580463Oct 1, 1995Paper

The TCR-beta chain repertoire of gut-derived T lymphocytes

Seminars in Immunology
A RegnaultA Cumano

Abstract

The gastrointestinal tract represents a natural barrier to environmental pathogens. The gut-associated lymphoid tissue (GALT) provides protection and interacts with the external environment, e.g. bacteria and food antigens. Large numbers of leukocytes are present as aggregates in the lymphoid follicles and as single cells in the lamina propria and epithelium. Intraepithelial T lymphocytes are localized within the tight junctions between epithelial cells. In conventional adult mice, they mainly express CD8, with half of the cells expressing the common CD8 molecule, the CD8 alpha beta heterodimer and the other half expressing a homodimer CD8 alpha alpha. The CD8 alpha beta IEL bear a TcR alpha beta while CD8 alpha alpha bear either a TcR gamma delta or a TcR alpha beta. Studies of repertoire with human IEL cell lines and with total human IEL population showed that both the alpha-chain and the beta-chain repertories are oligoclonal. Our own results of the analysis of repertoire diversity in genetically identical mice raised the same environment have shown that both CD8 alpha alpha and CD8 alpha beta TcR alpha beta IEL populations express a distinct oligoclonal repertoire that differs from one individual to the next. Compared to th...Continue Reading

Citations

Mar 7, 2014·Breast Cancer Research and Treatment·Amy C DegnimDaniel W Visscher
Oct 2, 2007·Immunology·A G EdwardsM Bailey
Feb 13, 2007·Immunological Reviews·Benedita Rocha
Apr 1, 1996·European Journal of Immunology·A RegnaultP Kourilsky
Feb 29, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·J L MatsudaR Aranda
Apr 12, 2007·Journal of Clinical Gastroenterology·Alessandro UbialiGabrio Bassotti

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.