Jan 16, 2010

The temperature-induced changes in membrane potential

Rivista di biologia
Stefanu Buzatu

Abstract

Excitability and response properties of a neuron may vary in different environmental conditions of temperature. Increase/decrease of membrane potential has been observed under increase/decrease of temperature in the external side of membrane compared with internal temperature, i.e. the internal cell environment becomes more electronegative/electropositive in relation to the external one. Changes in temperature affected the amplitude of action potentials, measured as the voltage difference between the threshold and the peak, and their duration, measured as the width of the action potential at the threshold. As the temperature is increased, the amplitude of action potential is decreased and its duration is reduced. This parameter may influence the functioning of a neuron through the temperature dependence of ion channel conductance and time constants of channel activation/inactivation factors. Alterations in temperature affect the rates of diffusion through ion channels, the rates of conformational changes that lead to their activation and inactivation, and the rates of the biochemical reactions with which ion channels are modulated and transported into and out of membranes. Measurements of the propagated action potentials at dif...Continue Reading

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Mentioned in this Paper

Tissue Membrane
Resting Potentials
Neurons
Action Potentials
Ion Channel
Biochemical Reaction
Interphase Cell
Excitability
Narrow Pore, Gated Channel Activity
Inactivation

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