PMID: 9192292May 1, 1997Paper

The temporal progression of the myelination defect in the taiep rat

Journal of Neurocytology
K F LunnI D Duncan

Abstract

The Sprague Dawley myelin mutant, the taiep rat, demonstrates a defect in CNS myelination which worsens with age and which is associated with abnormal accumulations of microtubules in oligodendrocytes. Quantitative and qualitative electron microscopic studies of myelin development and oligodendrocyte morphology were used to describe the temporal development of the defect in this mutant, in three regions of the CNS. The results indicate that the time of onset of myelination is similar in mutant and control rats, however the amount of myelin formed is reduced in the mutant, compared to controls, and there is a loss of myelin from the taiep CNS as the animals age. Thus the myelination defect in taiep has features of both hypomyelination and demyelination. Oligodendrocyte microtubule abnormalities were noted in each region of the taiep CNS at the time of onset of myelination. The earliest changes seen were close associations of oligodendrocyte microtubules with endoplasmic reticulum, with marked accumulations of microtubules filling the cytoplasm of oligodendrocytes from older taiep rats. These findings suggest that the microtubule abnormality in the taiep mutant inhibits both the initial formation and the long-term maintenance of ...Continue Reading

Citations

Jan 11, 2000·The Journal of General Psychology·A M AnchR R Richter
May 16, 2006·Toxicologic Pathology·Brad BolonUNKNOWN Ad Hoc Working Group of the STP Scientific and Regulatory Policy Committee
Mar 18, 2005·Neuropathology and Applied Neurobiology·A K Foote, W F Blakemore
Jun 15, 2006·Journal of Neuroscience Research·M R GalianoM E Hallak
Jun 26, 2020·Frontiers in Neuroscience·Angeles Garduno-RoblesVictor H Hernandez
Jul 13, 2005·Neuropathology and Applied Neurobiology·A K Foote, W F Blakemore
Mar 29, 2001·Physiological Reviews·N Baumann, D Pham-Dinh
Dec 8, 2007·Neuroscience Bulletin·Vincent Cazenave-LoustaletQiu-Shi Ren
Feb 5, 2000·Journal of Neuroscience Research·C Richter-Landsberg
Nov 26, 2010·Journal of Neuropathology and Experimental Neurology·Alastair WilkinsIan D Duncan
Apr 2, 2002·Molecular and Cellular Neurosciences·D R GoddardA M Butt
Feb 20, 2003·Brain Research·Bertha A León-ChávezDaniel Martinez-Fong
Dec 31, 2003·Molecular and Cellular Neurosciences·Jonathan SongIan D Duncan
Dec 30, 2006·Neuroscience Letters·Ma-del-Carmen CortésJosé-R Eguibar

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