The temporal/spatial evolution of optical signals in human cortex

Cerebral Cortex
A W TogaK L Black

Abstract

Intraoperative measures of functioning brain are an important aspect to understanding normal and diseased cortical response. Previous studies, in animal models, have used optical reflectance maps to illustrate the location and timing of functional activity. We used optical reflectance mapping in patients undergoing parietal tumor resection to reveal the temporal/spatial evolution of perfusion and other related metabolic responses of sensorimotor cortex to peripheral somesthetic stimulation. The somatosensory cortex of seven anesthetized patients was mapped in response to transcutaneous electrical median and ulnar nerve stimulation using optical reflectance imaging. The time course and spatial extent of this response were measured and correlated with evoked potential maps collected during the same conditions. Observable signals first appeared within 1-2 sec, peaked at 3 sec, and disappeared by 9 sec. These signals colocalized with the largest evoked potentials in both the sensory and motor regions and demonstrated topological specificity with median and ulnar nerve stimulation. Maps of this temporal/spatial resolution illustrate the integrative and dynamic nature of the neuronal, vascular, and metabolic responses of human cortex...Continue Reading

Citations

Jan 6, 2006·Journal of Neurophysiology·Nadja Van CampAnnemie Van der Linden
Jun 15, 2007·The Annals of Otology, Rhinology, and Laryngology·Tadashi Ishimaru
Nov 9, 2002·Journal of Neurophysiology·Alyssa M BaArthur W Toga
Mar 17, 1999·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M NemotoH Abe
Mar 18, 2005·Neurosurgical Focus·Nader PouratianArthur W Toga
Sep 24, 1998·Journal of Neurophysiology·A F CannestraA W Toga
Jun 15, 2004·Neuroreport·Theodore H SchwartzAnna W Roe
Apr 12, 2002·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Nader PouratianArthur W Toga
Oct 3, 2000·Journal of Neurosurgery·N PouratianA W Toga
Dec 25, 2002·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Hellmuth Obrig, Arno Villringer

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