The term 'non-radiographic axial spondyloarthritis' is much more important to classify than to diagnose patients with axial spondyloarthritis

Annals of the Rheumatic Diseases
A DeodharJuergen Braun

Abstract

The term axial spondyloarthritis (axSpA) now is used frequently to describe patients with predominantly axial symptoms who fit into the spectrum of a well-recognised rheumatic disease that continues to be known as ankylosing spondylitis (AS). The 2009 Assessment of SpondyloArthritis international Society (ASAS) classification criteria, developed to identify patients with early or atypical disease which could not be classified by the 1984 modified New York (mNY) criteria for AS, have led to a differentiation between non-radiographic axial spondyloarthritis (nr-axSpA) and radiographic axSpA, which is largely synonymous with AS. The main reason to distinguish between these ends of the spectrum of axSpA was that tumor necrosis factor (TNF) inhibitors (TNFi) approved for AS could obtain additional labelling for nr-axSpA and be used to treat all patients manifesting clinical features of axSpA. These two terms are distinguished by the degree of 'radiographic sacroiliitis' assessed by conventional radiography, according to the 1984 mNY criteria for AS. Since this differentiation has been shown to be not very reliable, we argue that the terms nr-axSpA and AS should only be used for classification of patients with axSpA and not as separa...Continue Reading

References

May 1, 1984·Radiology·J B VoglerH K Genant
May 22, 2003·Annals of the Rheumatic Diseases·A van TubergenSj van der Linden
Aug 10, 2006·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Per KjaerCharlotte Leboeuf-Yde
May 4, 2010·The Journal of Rheumatology·Percival D Sampaio-BarrosManoel B Bértolo
Feb 26, 2011·Annals of the Rheumatic Diseases·J Braun, X Baraliakos
May 5, 2011·Annals of the Rheumatic Diseases·Désirée van der HeijdeUNKNOWN Assessment of SpondyloArthritis international Society
Jan 26, 2012·Arthritis Care & Research·John D ReveilleMichael H Weisman
May 16, 2012·Annals of the Rheumatic Diseases·Kay-Geert A HermannUNKNOWN Assessment in SpondyloArthritis international Society (ASAS)
Dec 13, 2012·Arthritis and Rheumatism·Joachim Sieper, Désirée van der Heijde
Aug 21, 2013·Annals of the Rheumatic Diseases·Sofia RamiroRobert Landewé
Mar 22, 2014·The Spine Journal : Official Journal of the North American Spine Society·Cheng-Hui YangChen-Fen Chiu
Nov 17, 2014·The Journal of Rheumatology·Jurgen BraunJoachim Sieper
Dec 24, 2014·Seminars in Arthritis and Rheumatism·Annelies BoonenSameer Kotak
Mar 18, 2015·Arthritis Care & Research·Rohit AggarwalBrian M Feldman

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Citations

Mar 17, 2016·Annals of the Rheumatic Diseases·Daniel Wendling, Clément Prati
Jul 2, 2016·Zeitschrift für Rheumatologie·H Zeidler
Mar 17, 2017·Nature Reviews. Rheumatology·Jürgen Braun, Uta Kiltz
Apr 5, 2017·Current Opinion in Rheumatology·Barbara Neerinckx, Rik Lories
Jan 24, 2017·Lancet·Joachim Sieper, Denis Poddubnyy
May 19, 2018·Expert Review of Clinical Immunology·Mikhail Protopopov, Denis Poddubnyy
Dec 24, 2017·Arthritis Research & Therapy·Nilasha Ghosh, Eric M Ruderman
May 4, 2017·Annals of the Rheumatic Diseases·David S Pisetsky
Jan 15, 2017·Annals of the Rheumatic Diseases·Désirée van der HeijdeJürgen Braun
Nov 17, 2017·The Journal of Rheumatology·Ennio LubranoAntonio Marchesoni
Nov 1, 2018·Zeitschrift für Rheumatologie·J BraunU Kiltz
Feb 23, 2019·Rheumatology and Therapy·Philip C RobinsonStefan Siebert
Nov 13, 2019·International Journal of Rheumatic Diseases·Canan UnalMehmet Sinan Beksac
Feb 18, 2020·The Journal of Rheumatology·Marina N Magrey, Dilpreet Kaur Singh
Oct 1, 2020·Modern Rheumatology·Hideto KamedaTetsuya Tomita
Jun 27, 2018·Therapeutic Advances in Musculoskeletal Disease·Fabian Proft, Denis Poddubnyy
Jul 2, 2016·Expert Opinion on Biological Therapy·Julianna DesmaraisAtul Deodhar
Dec 28, 2018·Clinical Rheumatology·Abhijeet Danve, Atul Deodhar
Nov 30, 2019·International Journal of Rheumatic Diseases·James Cheng-Chung WeiUNKNOWN Taiwan Rheumatology Association (TRA)
Aug 4, 2019·Zeitschrift für Rheumatologie·J BraunU Kiltz
Jun 6, 2019·Arthritis Research & Therapy·Daniel E Furst, James S Louie
Jan 26, 2021·Therapeutic Advances in Musculoskeletal Disease·Bon San Koo, Tae-Hwan Kim
Apr 29, 2020·Rheumatic Diseases Clinics of North America·Rhys J Hayward, Pedro M Machado
Oct 17, 2020·The Journal of Rheumatology·Shao-Hsien LiuJonathan Kay
Oct 27, 2020·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Jessica A Walsh, Marina Magrey

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