PMID: 3749815Sep 1, 1986Paper

The terminal complement complex in sera deficient in the eighth component of complement (C8)

Scandinavian Journal of Immunology
T E MollnesF Tedesco

Abstract

The terminal complement complex (TCC) was quantified in sera from patients with a genetic deficiency of C8 alpha-gamma or C8 beta. The individual sera contained only trace amounts of TCC compared with a normal serum pool. The content of TCC increased after mixing the two sera, which was consistent with reconstitution of C8 activity. Only a moderate increase in TCC was obtained after zymosan activation of the individual sera, whereas activation of the mixture resulted in high amounts of TCC. C8 was demonstrated in the TCC of both deficient sera. These results may indicate that functional C8 is present in trace amounts despite the genetic deficiency, and that the terminal pathway may function to some extent although not enough to be detectable in less sensitive assays.

References

May 1, 1976·The Journal of Experimental Medicine·W P Klob, H J Müller-Eberhard
Nov 1, 1981·The Journal of Experimental Medicine·J TschoppH J Müller-Eberhard
Jan 1, 1983·Molecular Immunology·F TedescoG Sirchia
Sep 1, 1983·Clinical Immunology and Immunopathology·D P FineT F Lint
Jun 1, 1980·Clinical Immunology and Immunopathology·F TedescoG Sirchia

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Citations

Feb 1, 1988·Scandinavian Journal of Immunology·T E Mollnes, P J Lachmann
Jan 1, 1993·International Reviews of Immunology·F TedescoS Perissutti
Mar 1, 1991·Clinical and Experimental Immunology·R WürznerO Götze
Sep 22, 1998·Scandinavian Journal of Immunology·K HøgåsenF Tedesco

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