PMID: 2108622Apr 1, 1990Paper

The testicular effects of tumor necrosis factor

Annals of Surgery
K MealyD W Wilmore

Abstract

Tumor necrosis factor (TNF) is a cytokine that mediates many of the metabolic responses after endotoxemia, septicemia, and tissue injury. The effect of TNF on testicular function was determined in a series of studies in which rhTNF (0, 2, and 4 X 10(5) units/kg/24 hours) was administered by continuous infusion to male Wistar rats maintained on total parenteral nutrition adequate for growing rats. Testicular weight and histology, and plasma luteinizing hormone (LH), follicle-stimulating hormone (FSH), and testosterone levels were determined at 1, 3, and 6 days. Testicular weight decreased within 24 hours and this was associated with a fall in plasma testosterone and increased LH and FSH levels. These changes persisted for 6 days, indicating a loss of testosterone-mediated negative feedback on gonadotropin release. Histologic examination demonstrated significant damage to the germ cells in the adluminal compartment of the seminiferous epithelium; extensive exfoliation of spermatocytes and spermatids occurred at day six. However the primary spermatogonia in the basal compartment were relatively spared. Damage to the seminiferous epithelium at earlier times was noted in some tubules. The decrease in testosterone concentration and i...Continue Reading

References

Nov 1, 1976·Journal of Steroid Biochemistry·D EvainJ M Saez
Apr 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·L MilenkovicS M McCann
Jun 9, 1988·The New England Journal of Medicine·H R MichieD W Wilmore
Jul 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·D L Kilpatrick, C F Millette
Apr 1, 1987·The Journal of Clinical Endocrinology and Metabolism·E D LephartC R Parker
May 1, 1988·The Journal of Clinical Endocrinology and Metabolism·P R GindoffM Ferin
Oct 1, 1988·The Journal of Clinical Investigation·H F StarnesM F Brennan
Jun 1, 1985·The Journal of Trauma·C R Parker, C R Baxter
May 1, 1987·Molecular Endocrinology·R C ThompsonE Herbert
Jan 1, 1987·Journal of Steroid Biochemistry·N ChristeffE A Nunez
Jun 1, 1970·Journal of Reproduction and Fertility·Z TulassayA Czeizel
Jan 1, 1971·Proceedings of the Society for Experimental Biology and Medicine·R E Blackwell, M S Amoss
Sep 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·C L ChenC W Bardin
Sep 1, 1955·Endocrinology·Y CLERMONT, H MORGENTALER

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Citations

Sep 14, 1999·Endocrine·D B HalesK H Hales
Jul 17, 2008·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·A M O Leal, N T Foss
Dec 1, 1992·The Journal of Steroid Biochemistry and Molecular Biology·D B HalesI Tur-Kaspa
Mar 1, 2003·Journal of Reproductive Immunology·Mark P Hedger, Andreas Meinhardt
Jul 1, 1997·La Revue de médecine interne·C RoseB Devulder
Oct 1, 1994·Baillière's Clinical Endocrinology and Metabolism·S K GrinspoonJ P Bilezikian
Jul 16, 2011·Development and Psychopathology·Robert-Paul JusterSonia J Lupien
Feb 28, 2003·Biology of Reproduction·María O SuescunLivia Lustig
Nov 21, 2007·International Journal of Clinical Practice·F KaradagO Cildag
Jan 26, 1999·Annals of the New York Academy of Sciences·J G Cannon
Dec 14, 2004·American Journal of Respiratory and Critical Care Medicine·Franco LaghiMartin J Tobin
Jan 20, 2005·American Journal of Respiratory and Critical Care Medicine·Franco LaghiMartin J Tobin
Dec 12, 2007·BMC Physiology·Michael D HaywardOlesia Buiakova
Jul 26, 2011·Sports Medicine·Maren S FragalaJeff S Volek
Feb 9, 2016·Scandinavian Journal of Gastroenterology·Kristin Matre AasarødReidar Fossmark
Jul 22, 2004·The American Naturalist·Anne PetersBart Kempenaers
Jul 11, 2003·Chest·Richard DebigaréFrançois Maltais
Aug 26, 2006·Tropical Medicine & International Health : TM & IH·Angela M O LealNorma T Foss
Jan 25, 2012·Journal of Applied Toxicology : JAT·Yuki OgawaChisato Mori
Mar 1, 1993·Metabolism: Clinical and Experimental·T van der PollH P Sauerwein
Jul 19, 2005·Cytokine & Growth Factor Reviews·Weiliang XiaC Yan Cheng
Jun 7, 2015·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Mohanraj SadasivamChidambaram Prahalathan
Jan 22, 2002·Best Practice & Research. Clinical Endocrinology & Metabolism·D I Spratt
Aug 22, 2016·Molecular and Cellular Endocrinology·I V WagnerK Svechnikov
Jul 24, 2001·Biology of Reproduction·F El-GehaniI Huhtaniemi
Apr 23, 2002·Biology of Reproduction·Michelle Embree-KuKim Boekelheide
Sep 8, 2004·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Michelle K Y Siu, C Yan Cheng
Apr 29, 2015·Molecular and Cellular Biochemistry·Mohanraj SadasivamChidambaram Prahalathan
Nov 14, 2020·Journal of Pediatric Endocrinology & Metabolism : JPEM·Isabel Viola WagnerOlle Söder

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