The tetanus toxin model of chronic epilepsy

Advances in Experimental Medicine and Biology
Timothy A Benke, John Swann

Abstract

In experimental models of epilepsy, single and recurrent seizures are often used in an attempt to determine the effects of the seizures themselves on mammalian brain function. These models attempt to emulate as many features as possible of their human disease counterparts without many of the confounding factors such as underlying disease processes and medication effects. Numerous models have been used in the past to address different questions. Nevertheless, the basic questions are often the same: 1. Do seizures cause long-term damage? 2. Do seizures predispose to chronic epilepsy (epileptogenesis), that is long-term spontaneous repetitive seizures? 3. Are these results developmentally regulated? 4. Are the underlying mechanisms of epileptogenesis and brain damage related? In pursuing these questions, the goal is to determine how seizures exert their effects and to minimize any side effects from the methods employed to induce the seizures themselves. This requires a detailed characterization of the methods used to induce seizures. In this chapter, we will review the literature regarding the tetanus toxin model of chronic epilepsy with regard to its mechanisms of action, clinical comparisons, how it is experimentally implemented...Continue Reading

Citations

Aug 24, 2007·Journal of Child Neurology·Raman Sankar, Jong M Rho
Aug 15, 2014·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Pinar KuruFiliz Yilmaz Onat
Jun 16, 2007·Epilepsia·Cesare T Lombroso
May 15, 2012·Epilepsia·Marco MainardiMatteo Caleo

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