The TGF-β/Smad repressor TG-interacting factor 1 (TGIF1) plays a role in radiation-induced intestinal injury independently of a Smad signaling pathway.

PloS One
Mohammad HneinoFabien Milliat

Abstract

Despite advances in radiation delivery protocols, exposure of normal tissues during the course of radiation therapy remains a limiting factor of cancer treatment. If the canonical TGF-β/Smad pathway has been extensively studied and implicated in the development of radiation damage in various organs, the precise modalities of its activation following radiation exposure remain elusive. In the present study, we hypothesized that TGF-β1 signaling and target genes expression may depend on radiation-induced modifications in Smad transcriptional co-repressors/inhibitors expressions (TGIF1, SnoN, Ski and Smad7). In endothelial cells (HUVECs) and in a model of experimental radiation enteropathy in mice, radiation exposure increases expression of TGF-β/Smad pathway and of its target gene PAI-1, together with the overexpression of Smad co-repressor TGIF1. In mice, TGIF1 deficiency is not associated with changes in the expression of radiation-induced TGF-β pathway-related transcripts following localized small intestinal irradiation. In HUVECs, TGIF1 overexpression or silencing has no influence either on the radiation-induced Smad activation or the Smad3-dependent PAI-1 overexpression. However, TGIF1 genetic deficiency sensitizes mice to ra...Continue Reading

References

Feb 1, 1994·The Journal of Clinical Investigation·M H Barcellos-HoffJ A Weatherbee
Sep 1, 1996·International Journal of Radiation Biology·K Randall, J E Coggle
Oct 23, 1997·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·E J EhrhartM H Barcellos-Hoff
May 6, 1998·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·M S AnscherR L Jirtle
Nov 12, 1998·The American Journal of Pathology·J WangM Hauer-Jensen
Apr 13, 1999·Cell·D WottonJ Massagué
Dec 22, 1999·The Journal of Biological Chemistry·D WottonJ Massagué
May 10, 2000·International Journal of Radiation Oncology, Biology, Physics·M MartinS Delanian
Feb 22, 2001·Radiation Research·M E RobbinsS M Bonsib
Feb 24, 2001·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·L YangA Ghahary
Mar 14, 2002·The American Journal of Pathology·Kathleen C FlandersAnita B Roberts
Jun 14, 2002·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·James W Denham, Martin Hauer-Jensen
Aug 30, 2003·Oncogene·Paul DentSteven Grant
Apr 6, 2004·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Stefan Schultze-MosgauFranz Rödel
Jun 3, 2004·Proceedings of the National Academy of Sciences of the United States of America·Hirotaka FukasawaAkira Hishida
Dec 3, 2005·Genes & Development·Joan MassaguéDavid Wotton
Jan 24, 2006·Molecular and Cellular Biology·Laurent BartholinDavid Wotton
May 12, 2006·Kidney International·Y HuangN A Noble
May 18, 2006·Molecular and Cellular Biology·Lynn Mar, Pamela A Hoodless
Sep 9, 2006·Journal of the American Society of Nephrology : JASN·Ruoyun TanYouhua Liu
Dec 8, 2006·Radiation Research·Michael F JoblingMary Helen Barcellos-Hoff
Feb 24, 2007·Current Opinion in Cell Biology·Susumu Itoh, Peter ten Dijke
Dec 7, 2007·International Journal of Radiation Biology·Kumari L AndarawewaMary Helen Barcellos-Hoff
Feb 16, 2008·The American Journal of Pathology·Fabien MilliatAgnès François
Apr 11, 2008·American Journal of Physiology. Cell Physiology·Valérie HaydontMarie-Catherine Vozenin-Brotons
May 30, 2008·Developmental Biology·Laurent BartholinDavid Wotton
Dec 31, 2008·Cell Research·Julien Deheuninck, Kunxin Luo
Jan 17, 2009·International Journal of Radiation Oncology, Biology, Physics·Marion ScharpfeneckerFiona A Stewart
Jan 17, 2009·Nature Reviews. Cancer·Gillian C BarnettNeil G Burnet
Jul 7, 2009·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Marion ScharpfeneckerFiona A Stewart
Jan 29, 2011·The Biochemical Journal·Xiaohua Yan, Ye-Guang Chen

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Citations

Apr 23, 2013·Cellular Signalling·Luqing ZhaoYa Cao
Mar 25, 2017·International Journal of Molecular Sciences·Michael T EadonM Eileen Dolan
Sep 22, 2012·The Journal of Biological Chemistry·Mohammad HneinoFabien Milliat
Jun 4, 2019·The EMBO Journal·Parash ParajuliAzeddine Atfi
Jul 4, 2019·The EMBO Journal·Parash ParajuliAzeddine Atfi
Jun 25, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Guo XiangWu Weiming

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Methods Mentioned

BETA
nuclear translocation
ubiquitination
PCR
Transfection
electrophoresis

Software Mentioned

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Visiol

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