The thalamus and midbrain in Reye syndrome

Pediatric Neurology
Stanley D Johnsen, C Roger Bird

Abstract

A previously healthy 5 1/2-year-old male had Reye syndrome. He presented in coma with apnea 1 week after a viral infection and following 2 days of vomiting and progressive obtundation. He was in coma with dystonic posturing and intact brainstem function. Laboratory evaluation revealed initial hypoglycemia, and markedly elevated liver enzymes, prolonged clotting times, and elevated ammonia levels. No underlying metabolic disorder was present, and the patient completely recovered. On a modified diffusion-weighted image magnetic resonance imaging scan, restriction of diffusion in the thalamus and midbrain was observed. While abnormalities of the thalamus and midbrain have previously been reported, this is the first report of diffusion-weighted imaging indicating early impairment of water diffusion, a finding more commonly observed with stroke.

References

Sep 2, 1999·Critical Care Medicine·J P Orlowski
Sep 2, 1999·Critical Care Medicine·A P Sarnaik
Feb 22, 2003·European Journal of Radiology·Roland Bammer
Nov 12, 2003·Neurology·Takahiro IizukaNorihiro Suzuki
Sep 29, 2004·Journal of the Neurological Sciences·Dong Wook KimSangYun Kim
Nov 13, 2004·Journal of Computer Assisted Tomography·Mahesh PrakashRakesh K Gupta

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Citations

Nov 24, 2011·AJR. American Journal of Roentgenology·Paritosh C KhannaDennis W W Shaw
Jun 3, 2011·Journal of Child Neurology·Paramdeep SinghArchana Ahluwalia
Sep 14, 2013·The Neuroradiology Journal·M GallucciC Micheli

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