The theaflavin monomers inhibit the cancer cells growth in vitro

Acta Biochimica Et Biophysica Sinica
Youying TuNaoharu Watanabe

Abstract

The inhibition effects of tea theaflavins complex (TFs), theaflavin-3-3'-digallate (TFDG), theaflavin-3'-gallate (TF2B), and an unidentified compound (UC) on the growth of human liver cancer BEL-7402 cells, gastric cancer MKN-28 cells and acute promyelocytic leukemia LH-60 cells were investigated. TFs was obtained through the catalysis of catechins with immobilized polyphenols oxidase. TFDG, TF2B and UC were isolated from TFs with high speed countercurrent chromatography (HSCCC). The results showed that TF2B significantly inhibited the growth of all three kinds of cancer cells, TFs, TFDG and UC had some effect on BEL-7402 and MKN-28, but little activity on LH-60. The inhibition effects of TF2B, TFDG, and UC on BEL-7402 and MKN-28 were stronger than TFs. The relationship coefficients between monomer concentration and its inhibition rate against MKN-28 and BEL-7402 were 0.87 and 0.98 for TF2B, 0.96 and 0.98 for UC, respectively. The IC50 values of TFs, TF2B, and TFDG were 0.18, 0.11, and 0.16 mM on BEL-7402 cells, and 1.11, 0.22, and 0.25 mM on MKN-28 cells respectively.

Citations

May 28, 2010·Journal of Zhejiang University. Science. B·Wei LiYou-ying Tu
Mar 28, 2013·Nutrition and Cancer·Altaf S Darvesh, Anupam Bishayee
Jul 6, 2017·Critical Reviews in Food Science and Nutrition·Kwan-Wai NgTao Yi
Apr 1, 2015·SpringerPlus·Katarína KoňarikováIngrid Žitňanová
Sep 15, 2010·Free Radical Research·Agnieszka AugustyniakNeven Zarković
Feb 20, 2010·Journal of Separation Science·Fernanda das Neves Costa, Gilda Guimarães Leitão
Mar 7, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Eric J O'NeillEvangelia Tsiani

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