PMID: 2092098Apr 1, 1990Paper

The theory of chronic deafferentation dysesthesias

Journal of Neurosurgical Sciences
M Levitt

Abstract

The chronic dysesthesias are abnormal disturbing somatic sensations, which are painful or non-painful. Their abnormality is revealed by their null or distorted psychophysical relationships; they occur spontaneously or can be peripherally induced by innocuous or noxious stimuli. Among nonverbal or mentally incompetent humans and also subhumans, these dysesthesias are expressed by patterns of escape or avoidance behaviors. There is no contemporaneous and necessary relationship with peripheral nociception. The basic mechanisms of these abnormalities have been obscure, and conventional modes of therapy have been unsuccessful. The origin of these chronic abnormalities is known to arise from lesions of peripheral or central components of the neural pathway for normal pain and temperature sensibility. The cause of these abnormalities is thought to reside in pathophysiological foci of excitability among deafferented central nocireceptive neurons. The spontaneous dysesthesias can occur after partial or total deafferentation. The peripherally induced dysesthesias occur after partial deafferentations, which include loss of small caliber myelinated afferents in cases of peripheral origin; and they are mediated via remaining afferent pathwa...Continue Reading

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.