Abstract
To evaluate whether anticholinergic medication contributes to early recovery of continence and improvement of other voiding symptoms after radical prostatectomy (RP). A total of 78 patients with clinically localized prostate cancer who had incontinence at 1 week after RP were enrolled prospectively. The patients were allocated to one of the 2 groups: group 1 (α-adrenergic agonist [midodrine] plus an anticholinergic [solifenacin]) or group 2 (α-adrenergic agonist only). A urodynamic study and the International Continence Society male Short Form questionnaire were completed preoperatively and 4 months after RP. One-hour pad test and 3-day frequency volume chart at 1 and 4 months after medication were also analyzed. The rate of continence, defined as being pad free, did not differ between the groups at 4 months (both 71.8%; P >.05). However, the decreased value of mean weight of daily pads worn by groups 1 and 2 were 51.5 vs 11.7 g, respectively (P = .005). The incontinence (P = .008) and quality of life (P = .044) subscale scores significantly worsened in group 2, whereas they remained unchanged in group 1. Maximal detrusor pressure and maximal urethral closure pressure significantly decreased in both groups, whereas maximal cyst...Continue Reading
References
Jan 1, 1997·World Journal of Urology·U JonasT H Holmdahl
Sep 24, 1998·International Urogynecology Journal and Pelvic Floor Dysfunction·E H WeilW Wein
Jun 26, 2002·BJU International·M PeyromaureL Boccon-Gibod
Apr 2, 2004·Urological Research·C DeliveliotisV Protogerou
Jul 5, 2005·Urology·Shunichi NamikiYoichi Arai
Jul 27, 2006·International Urology and Nephrology·Dionisios MitropoulosAris Giannopoulos
Aug 9, 2006·International Journal of Clinical Practice·C R ChappleF E Govier
Sep 1, 2006·European Urology·Maria Teresa FilocamoGiulio Nicita
Apr 4, 2007·European Urology·Massimo PorenaAntonella Giannantoni
May 8, 2009·Biomedical Research·Saori NishijimaMinoru Miyazato
Feb 5, 2010·BJU International·Cheryn SongHanjong Ahn
Apr 27, 2010·International Journal of Urology : Official Journal of the Japanese Urological Association·UNKNOWN Committee for Establishment of the Clinical Guidelines for Nocturia of the Neurogenic Bladder Society
Apr 5, 2011·European Urology·Ricarda M BauerChristian G Stief
May 24, 2011·Urology·Osamu YamaguchiUNKNOWN ASSIST Study Group
Sep 29, 2011·BJU International·Martin BoettcherRuth Kirschner-Hermanns
Mar 2, 2012·International Journal of Urology : Official Journal of the Japanese Urological Association·Katsumi KadekawaKimio Sugaya
Jun 16, 2012·CA: a Cancer Journal for Clinicians·Rebecca SiegelElizabeth Ward
Jul 27, 2012·European Urology·Steven A KaplanAllam Fakhoury
Citations
Aug 25, 2016·Drugs & Aging·Anja LøvvikHitendra R H Patel
Jul 28, 2017·Fukushima Journal of Medical Science·Nobuhiro HagaYoshiyuki Kojima
Feb 13, 2018·Experimental and Therapeutic Medicine·Baodi ZhangJunrong Wang
Oct 12, 2018·Current Urology Reports·Benoit Peyronnet, Benjamin M Brucker
Jul 1, 2017·The Journal of International Medical Research·Ranxing YangJianjun Yu
Nov 6, 2020·The World Journal of Men's Health·Nicolò SchifanoAndrea Salonia
Jul 18, 2020·Current Drug Targets·Vasileios Sakalis, Anastasia Gkotsi