The therapeutic effect of solifenacin succinate on the recovery from voiding dysfunction after radical prostatectomy in men with clinically localized prostate cancer: a prospective, randomized, controlled study

Urology
Myungsun ShimHanjong Ahn

Abstract

To evaluate whether anticholinergic medication contributes to early recovery of continence and improvement of other voiding symptoms after radical prostatectomy (RP). A total of 78 patients with clinically localized prostate cancer who had incontinence at 1 week after RP were enrolled prospectively. The patients were allocated to one of the 2 groups: group 1 (α-adrenergic agonist [midodrine] plus an anticholinergic [solifenacin]) or group 2 (α-adrenergic agonist only). A urodynamic study and the International Continence Society male Short Form questionnaire were completed preoperatively and 4 months after RP. One-hour pad test and 3-day frequency volume chart at 1 and 4 months after medication were also analyzed. The rate of continence, defined as being pad free, did not differ between the groups at 4 months (both 71.8%; P >.05). However, the decreased value of mean weight of daily pads worn by groups 1 and 2 were 51.5 vs 11.7 g, respectively (P = .005). The incontinence (P = .008) and quality of life (P = .044) subscale scores significantly worsened in group 2, whereas they remained unchanged in group 1. Maximal detrusor pressure and maximal urethral closure pressure significantly decreased in both groups, whereas maximal cyst...Continue Reading

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Citations

Aug 25, 2016·Drugs & Aging·Anja LøvvikHitendra R H Patel
Jul 28, 2017·Fukushima Journal of Medical Science·Nobuhiro HagaYoshiyuki Kojima
Oct 12, 2018·Current Urology Reports·Benoit Peyronnet, Benjamin M Brucker
Jul 1, 2017·The Journal of International Medical Research·Ranxing YangJianjun Yu
Nov 6, 2020·The World Journal of Men's Health·Nicolò SchifanoAndrea Salonia
Jul 18, 2020·Current Drug Targets·Vasileios Sakalis, Anastasia Gkotsi

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