The therapeutic effects of daphnetin in collagen-induced arthritis involve its regulation of Th17 cells

International Immunopharmacology
Lina TuNanzhen Kuang

Abstract

Daphne odora var. marginata (D. marginata), an aiophyllus arbuscular plant, is one of the traditional Chinese medicines used to treat rheumatoid arthritis. This study investigated the therapeutic effects and mechanisms of daphnetin, an active monomer ingredient derived from D. marginata, on collagen-induced arthritis (CIA) in rats. The effects of daphnetin on joint diseases were assessed by hematoxylin and eosin staining and radiographic and transmission electron microscopy. The protein and mRNA expression levels of T helper (Th)1/Th2/Th17-type cytokines in the spleen were determined by flow cytometry and quantitative real-time PCR. Our results showed that daphnetin significantly reduced paw swelling and was nontoxic in vivo at the tested doses. Synovial hyperplasia, joint destruction and chondrocyte degeneration in CIA rats were suppressed by daphnetin. Daphnetin treatment also reduced the levels of Th1/Th2/Th17 type cytokines in spleen lymphocytes in CIA rats. Moreover, the expression of Foxp3, which can down-regulate the activity of Th17 cells, was significantly increased in the daphnetin-treated groups. These results suggest that daphnetin may have therapeutic effects in down-regulating Th17-type responses in CIA rats. The ...Continue Reading

References

Oct 20, 1998·International Journal of Immunopharmacology·W Z Gu, S R Brandwein
Dec 10, 2003·The Journal of Experimental Medicine·Craig A MurphyDaniel J Cua
Dec 8, 2004·Current Pharmaceutical Design·Konstantina C FylaktakidouDemetrios N Nicolaides
Jan 20, 2005·The Journal of Experimental Medicine·Claire L LangrishDaniel J Cua
Jan 5, 2007·Annual Review of Immunology·Casey T WeaverLaurie E Harrington
Mar 31, 2007·Natural Product Research·W ZhangL Shan
Jul 12, 2007·Proceedings of the National Academy of Sciences of the United States of America·Akihiro KimuraTadamitsu Kishimoto
May 31, 2008·Cell·Shimon SakaguchiMasahiro Ono
Oct 7, 2008·Journal of Ethnopharmacology·Qin GaoHuiqin Xu
Feb 4, 2010·Seminars in Immunopathology·Erik Lubberts

❮ Previous
Next ❯

Citations

Feb 5, 2016·Biochemical and Biophysical Research Communications·Hiroki FukudaEishi Ashihara
Jun 13, 2015·Archivum Immunologiae Et Therapiae Experimentalis·Jacek TabarkiewiczKrzysztof Giannopoulos
Jan 4, 2015·Chinese Journal of Integrative Medicine·Wen-Jun Xu, Ju-Sheng Wang
Jun 15, 2016·Clinical and Experimental Pharmacology & Physiology·Abhishek KumarShakti Prasad Pattanayak
Jun 2, 2017·Phytotherapy Research : PTR·Majid Asadi-SamaniHedayatollah Shirzad
May 31, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jianjian JiLiyun Shi
Mar 4, 2014·Molecular Medicine Reports·Zhi-Yong LiuWei-Xing Wang
Sep 14, 2019·Phytotherapy Research : PTR·Xu-Zhao Li, Shuai-Nan Zhang
May 22, 2018·Frontiers in Pharmacology·Ian F Caplan, Kathleen A Maguire-Zeiss
May 8, 2020·Oxidative Medicine and Cellular Longevity·Emad H M HassaneinAyman M Mahmoud
Nov 25, 2014·Journal of Agricultural and Food Chemistry·Wen-Wen YuLi-Yun Shi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here