The therapeutic efficacy and prophylactic activity of doramectin against Dictyocaulus viviparus in cattle

Australian Veterinary Journal
N J BartonJ Reynolds

Abstract

Three groups of 8, 4-month-old male Jersey or Jersey-cross calves were infected with 2400 Dictyocaulus viviparus L3 larvae and either left untreated or injected subcutaneously with 200 micrograms/kg doramectin 5 or 25 days after infection (DAI). Lungworms were found in all untreated cattle (geometric mean = 49) at necropsy 39 or 40 DAI. None was found in any of the treated cattle. In a second experiment, groups of 6, 8-month-old calves were untreated or injected with 200 micrograms/kg doramectin 28, 21 or 14 days before each calf was challenged with 2700 D viviparus larvae. Lungworms were recovered at necropsy 32 to 34 DAI. The geometric mean worm burden in the untreated cattle was 550. This was reduced by 100%, 99.5% and 94.1% in calves treated with doramectin 14, 21 or 28 days, respectively, before infection. It was concluded that doramectin is a highly effective anthelmintic against D viviparus adult or L4 infections of cattle, and that reinfection of treated cattle will be significantly reduced for at least 28 days after treatment.

References

Jul 1, 1993·Veterinary Parasitology·S R WicksD G Smith
Jul 1, 1993·Veterinary Parasitology·A C GoudieA J Weatherley
Jul 1, 1993·Veterinary Parasitology·N B LoganD J Shanks

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Citations

Jul 19, 2013·The Korean Journal of Parasitology·Maha M A Basyoni, Abdel-Aleem A El-Sabaa
Mar 16, 1996·The Veterinary Record·G BanethA Keysary

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Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.

Anthelmintics (ASM)

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