The therapeutic efficacy of 177Lu-DOTATATE/DOTATOC in advanced neuroendocrine tumors: A meta-analysis.

Medicine
Li-Fan WangYong Li

Abstract

Somatostatin analog therapies showed great potential for patients suffering advanced neuroendocrine tumors (NETs). This study was aimed to evaluate the therapeutic efficacy of Lu-DOTATATE/DOTATOC (Lu-octreotate/octreotide) peptide receptor radionuclide therapy (PRRT) in advanced or inoperable NETs patients. Pubmed, Web of Science, Embase and Cochrane Library were searched from 1950 to April 2019. Eligible studies should include randomized or nonrandomized controlled trials (RCTs)-based investigations of Lu-octreotate/octreotide PRRT for NETs. All these studies were assessed with Response Evaluation Criteria in Solid Tumors (RECIST), RECIST 1.1, Southwest Oncology Group (SWOG) criteria or World Health Organization (WHO) criteria. Disease response rates (DRRs) and disease control rates (DCRs) were calculated according to each response criteria group. DRRs were defined as the percentages of patients with complete response (CR) + partial response (PR), while DCRs represented the percentages of patients with CR+ PR+ stable disease (SD). The pooled proportions were calculated with either a fixed-effects model or a random-effects model depending on the test for heterogeneity. A total of 22 studies (1758 patients) were included in this...Continue Reading

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Citations

Aug 23, 2020·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Qingxing LiuXiaoyuan Chen
Mar 16, 2021·Current Oncology Reports·N S MinczelesT Brabander
Jun 30, 2021·Current Opinion in Oncology·Carlos ArtigasIoannis Karfis
Jul 30, 2021·Nuklearmedizin. Nuclear Medicine·Siroos MirzaeiRoland Hustinx

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