The Therapeutic Pipeline for Pseudomonas aeruginosa Infections

ACS Infectious Diseases
Lori L Burrows

Abstract

Pseudomonas aeruginosa is a Gram-negative opportunistic pathogen, designated by the World Health Organization as a critical priority for development of new therapeutics due to high levels of intrinsic and acquired antibiotic resistance. Other challenges include its versatility (it can persist in the environment and most strains are capable of causing disease in compromised hosts), robust efflux mechanisms that limit drug penetration, and the propensity to form antimicrobial-tolerant biofilms. Novel therapeutics in development to prevent or treat P. aeruginosa infections include vaccines, biologics such as antimicrobial peptides and therapeutic antibodies, virulence inhibitors, antimicrobials with novel targets, antibody-drug conjugates, resistance inhibitor-antibiotic or antibiotic-potentiator combinations, and bacteriophages or phage-derived lysins.

References

Sep 6, 2000·Molecular Microbiology·S Mahajan-MiklosF M Ausubel
Aug 27, 2005·Nature·Lucas R HoffmanSamuel I Miller
Aug 25, 2009·The Journal of Hospital Infection·K G Kerr, A M Snelling
Jul 3, 2010·Critical Care : the Official Journal of the Critical Care Forum·Karen Bush
Jun 18, 2011·Infectious Disorders Drug Targets·Damien Roux, Jean-Damien Ricard
Jun 30, 2012·The European Respiratory Journal·Matthew N HurleyAlan R Smyth
Jul 26, 2012·Biophysical Journal·Yi ShenHoward A Stone
Aug 14, 2012·Environmental Microbiology·V BehrendsH D Williams
Nov 13, 2013·Expert Opinion on Investigational Drugs·Ze-Qi XuJohn Flavin
May 21, 2014·Antimicrobial Agents and Chemotherapy·Paul WarrenerC Kendall Stover
May 24, 2014·PLoS Pathogens·César de la Fuente-NúñezRobert E W Hancock
Nov 14, 2014·Science Translational Medicine·Antonio DiGiandomenicoC Kendall Stover
Jan 8, 2015·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Timothy J KiddUNKNOWN ACFBAL Study Investigators
Apr 18, 2015·Current Medicinal Chemistry·Agata Dorotkiewicz-JachZuzanna Drulis-Kawa
Jul 15, 2015·PLoS Biology·Nuno M OliveiraKevin R Foster
Aug 25, 2015·The Cochrane Database of Systematic Reviews·Helle Krogh Johansen, Peter C Gøtzsche
Nov 27, 2015·The Lancet Infectious Diseases·Tomislav KostyanevHerman Goossens
Dec 22, 2015·International Journal of Medical Microbiology : IJMM·Maitrayee ChatterjeeRaja Biswas
Jan 26, 2016·Journal of Medicinal Chemistry·Stefanie WagnerAlexander Titz
Mar 8, 2016·Trends in Microbiology·Craig WinstanleyMichael A Brockhurst
Mar 8, 2016·Current Medicinal Chemistry·Hannah Y MahmoodKhondaker M Rahman
May 27, 2016·Scientific Reports·Benjamin K ChanPaul E Turner
May 29, 2016·Cold Spring Harbor Perspectives in Medicine·Alice L Erwin
Jun 9, 2016·FEMS Microbiology Reviews·Michael A Welsh, Helen E Blackwell
Jun 16, 2016·Scientific Reports·Katarzyna Danis-WlodarczykZuzanna Drulis-Kawa
Jul 30, 2016·Nature Reviews. Drug Discovery·Kevin OuttersonJoseph Larsen
Aug 19, 2016·MMWR. Morbidity and Mortality Weekly Report·Jennifer R CopeMichelle E Tarver
Jan 12, 2017·The Journal of Antibiotics·Pamela Brown, Michael J Dawson
Jan 14, 2017·Frontiers in Cellular and Infection Microbiology·Margit MahlapuuCamilla Björn
Feb 6, 2017·Critical Care : the Official Journal of the Critical Care Forum·Jordi RelloKerstin Westritschnig
Feb 7, 2017·International Journal of Antimicrobial Agents·Katy JeannotPatrick Plésiat
Mar 7, 2017·Clinical and Experimental Pharmacology & Physiology·Anna ErmundGunnar C Hansson

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Citations

Jul 3, 2019·Antimicrobial Agents and Chemotherapy·Michael R M RanieriLori L Burrows
Dec 3, 2020·Frontiers in Cellular and Infection Microbiology·Tânia GrainhaMaria Olívia Pereira
Sep 8, 2019·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·João BotelhoLuísa Peixe
Nov 5, 2019·Microbial Pathogenesis·Florencia Fátima FerramolaMaría Aída Mattar Domínguez
Sep 2, 2020·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Gopal Ramamourthy, Hans J Vogel
Jan 29, 2021·Infection and Drug Resistance·Fengjuan TianYigang Tong
Jun 3, 2021·International Journal of Molecular Sciences·Giada AntonelliFrancesca Schiavetti
Jul 30, 2021·Proceedings of the National Academy of Sciences of the United States of America·Charlotte E MeliaTanmay A M Bharat
May 1, 2019·Journal of the American Chemical Society·Achala N D Punchi HewageMario Rivera
Mar 12, 2020·ACS Infectious Diseases·Declan Alan Gray, Michaela Wenzel
Jul 13, 2021·Microbiology and Immunology·Shahinur AkterTomohiro Sawa

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