The Therapeutic Potential of Blocking Galectin-3 Expression in Acute Myocardial Infarction and Mitigating Inflammation of Infarct Region: A Clinical Outcome-Based Translational Study.

Biomarker Insights
Wassim MoslehUmesh C Sharma

Abstract

Increased galectin-3 is associated with ischemic cardiomyopathy, although its role in early remodeling post-myocardial infarction (MI) has not been fully elucidated. There are no data demonstrating that blocking galectin-3 expression would have an impact on the heart and that its relationship to remodeling is not simply an epiphenomenon. The direct association between galectin-3 and myocardial inflammation, dysfunction, and adverse cardiovascular outcomes post-MI was examined using clinical and translational studies. We performed expression analysis of 9753 genes in murine model of acute MI. For galectin-3 loss of function studies, homozygous galectin-3 knock-out (KO) mice were subjected to coronary artery ligation procedure to induce acute MI (MI, N = 6; Sham, N = 6). For clinical validation, serum galectin-3 levels were measured in 96 patients with ST-elevation MI. Echocardiographic and angiographic parameters of myocardial dysfunction and 3-month composite outcome including mortality, recurrent MI, stroke, and heart failure hospitalization were measured. In the infarct regions of murine models, galectin-3 was a robustly expressed gene. Elevated galectin-3 expression strongly correlated with macrophage-mediated genes. Galecti...Continue Reading

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Citations

Aug 14, 2018·European Journal of Clinical Investigation·Christopher AdlbrechtAlberto Bouzas-Mosquera
Feb 14, 2019·British Journal of Pharmacology·Xiao-Jun DuHelen Kiriazis
May 3, 2019·Current Eye Research·Yi LiuJianhua Wang
Nov 13, 2020·The International Journal of Biochemistry & Cell Biology·R J SlackA C Mackinnon

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Methods Mentioned

BETA
PCR
Enzyme-linked Immunosorbent Assays

Software Mentioned

SPSS
ImageJ

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