The Therapeutic Potential of D-Amino Acid Oxidase (DAAO) Inhibitors.

The Open Medicinal Chemistry Journal
Sean M SmithPeter H Hutson

Abstract

D-amino acid oxidase (DAAO) is a flavoenzyme that degrades D-amino acids through the process of oxidative deamination. DAAO regulation of D-amino acid levels has been associated with several physiological processes ranging from hormone secretion to synaptic transmission and cognition. Recent genetic studies have identified a mutation on chromosome 13 in schizophrenia patients that encodes two gene products (G30 and G72) that are associated with DAAO. Furthermore, DAAO expression and enzyme activity has been reported to be increased in post mortem brain tissue samples from patients with schizophrenia compared to healthy controls. D-serine, a D-amino acid that is regulated by DAAO, is a potent, endogenous co-agonist of the N-methyl-D-aspartic acid (NMDA) receptor. Because NMDA receptor dysfunction is thought to be involved in the positive (psychotic), negative and cognitive symptoms in schizophrenia, there has been much interest in developing potent and selective DAAO inhibitors for the treatment of this disease. Several research reports have been published that describe the synthesis and biological effects of novel, selective, small molecule inhibitors of DAAO. Many of these compounds have been shown, when given systemically, to...Continue Reading

References

Jan 1, 1991·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·M KatagiriT Yamano
Jan 1, 1993·Trends in Pharmacological Sciences·J A Kemp, P D Leeson
Nov 1, 1996·The British Journal of Psychiatry : the Journal of Mental Science·U Heresco-LevyD Kelly
Aug 15, 1998·Biochemical and Biophysical Research Communications·Y TakigawaK Imai
Dec 4, 1998·Biological Psychiatry·G TsaiJ T Coyle
Jan 19, 1999·Archives of General Psychiatry·U Heresco-LevyM Lichtenstein
Apr 26, 2000·Proceedings of the National Academy of Sciences of the United States of America·J P MothetS H Snyder
Dec 29, 2000·Cellular and Molecular Life Sciences : CMLS·M S Pilone
May 10, 2001·Biological Psychiatry·A C LahtiC A Tamminga
Nov 8, 2001·European Journal of Pharmacology·C G Parsons
Mar 1, 2002·The American Journal of Psychiatry·Uriel Heresco-LevyDaniel C Javitt
Oct 5, 2002·Proceedings of the National Academy of Sciences of the United States of America·Ilya ChumakovJohn Realson
Mar 18, 2004·American Journal of Physiology. Endocrinology and Metabolism·Hiroshi HasegawaTakao Hashimoto
Jun 9, 2005·Progress in Neuro-psychopharmacology & Biological Psychiatry·Kenji HashimotoMasaomi Iyo
Jul 6, 2005·Neuroscience Research·Masao MaekawaYuuichi Hori
Oct 14, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Maria ShleperHerman Wolosker
Dec 13, 2006·Schizophrenia Research·Inna BendikovGalila Agam
Apr 13, 2007·American Journal of Physiology. Renal Physiology·Alexander W KrugStefan Silbernagl
Aug 8, 2007·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Tiziana AdagePaola Zaratin
Sep 7, 2007·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Kenji HashimotoMasaomi Iyo
Sep 18, 2007·Cellular and Molecular Neurobiology·Wenjuan ZhaoYong-Xiang Wang
Sep 21, 2007·The European Journal of Neuroscience·Louise VerrallPhilip W J Burnet
Apr 4, 2008·European Journal of Pharmacology·Kenji ItoAtsushi Hashimoto
May 6, 2008·Bioorganic & Medicinal Chemistry Letters·Tim SpareyMary Beth Young
May 30, 2008·Journal of Medicinal Chemistry·Dana FerrarisTakashi Tsukamoto
Jun 19, 2008·Molecular Psychiatry·P W J BurnetP J Harrison
Oct 17, 2008·Pharmacological Reviews·Jeffrey A LiebermanJohn G Csernansky

❮ Previous
Next ❯

Citations

Apr 27, 2011·Amino Acids·Mendel Friedman, Carol E Levin
Aug 16, 2012·Amino Acids·Masahiro YamanakaRyuichi Konno
Sep 22, 2012·Amino Acids·Jin-Lu HuangYong-Xiang Wang
Jul 2, 2011·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Sumiko IwasaTakeshi Fukushima
Jul 26, 2012·ISRN Pharmacology·Kyra-Verena SendtDerek K Tracy
Oct 17, 2015·Expert Opinion on Investigational Drugs·Nebojsa Nick KnezevicKenneth D Candido
Mar 15, 2011·Trends in Biotechnology·Loredano Pollegioni, Gianluca Molla
Oct 17, 2015·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Camilo RojasBarbara S Slusher
Jul 17, 2012·Neuropharmacology·Graham L CollingridgeDavid E Jane
Nov 26, 2010·Biochemical Pharmacology·Garret O'ConnellJeremy Hall
Dec 24, 2013·International Journal of Molecular Sciences·Sunny Li-Yun ChangHao-Teng Chang
Apr 13, 2018·Journal of Neurotrauma·Sigal Liraz-ZaltsmanEsther Shohami
Sep 18, 2018·Expert Opinion on Drug Discovery·Bence SzilágyiGyörgy M Keserű
Jan 17, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Bence SzilágyiGyörgy M Keserű
Feb 3, 2012·Current Opinion in Psychiatry·Joshua Kantrowitz, Daniel C Javitt
Jun 9, 2017·Scientific Reports·Qingju LiuYujian He
Sep 25, 2019·Nutrients·Jacco J A J BastingsSander S Rensen
Mar 12, 2016·World Journal of Surgery·Dirk T UbbinkMark J Koelemay
Dec 12, 2020·The International Journal of Neuropsychopharmacology·Lili Veronika NagyIstván Hernádi
Jul 25, 2021·International Journal of Molecular Sciences·Mark W SherwoodAude Panatier
Jul 16, 2011·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Hiroko OhideRyuichi Konno

❮ Previous
Next ❯

Methods Mentioned

BETA
deamination
X-ray
pharmacotherapy

Software Mentioned

Sepracor

Related Concepts

Related Feeds

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here