The Therapeutic Potential of PI3K/Akt/mTOR Inhibitors in Breast Cancer: Rational and Progress

Journal of Cellular Biochemistry
Afsane BahramiAmir Avan

Abstract

Breast cancer (BC) is the most commonly diagnosed cancer in women. The PI3K/AKT/mTOR pathway is among the most frequently dysregulated pathways in patients with BC. The activation of this pathway is associated with increased cell growth and clinical outcome, and its overexpression is associated with a poor prognosis. It has been proposed that it may be of importance as a potential therapeutic target in the treatment of BC. The aim of current review is to provide an overview of the potential utility of PI3K/Akt/mTOR inhibitors in patients with BC, with particular emphasis on recent preclinical and clinical studies. J. Cell. Biochem. 119: 213-222, 2018. © 2017 Wiley Periodicals, Inc.

References

Aug 30, 2000·Nature·C M PerouD Botstein
Jun 1, 2002·Science·Lewis C Cantley
Dec 13, 2005·Nature Reviews. Drug Discovery·Bryan T HennessyGordon B Mills
Jan 26, 2007·Expert Opinion on Biological Therapy·Filippo MontemurroMassimo Aglietta
Feb 6, 2007·Drug Discovery Today·Chi Kwan TsangX F Steven Zheng
Jul 7, 2007·Cancer Cell·David A Guertin, David M Sabatini
Jan 4, 2008·Histopathology·J S Reis-Filho, A N J Tutt
May 6, 2008·Cell·Leonardo SalmenaPier Paolo Pandolfi
Sep 30, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Stephen JohnstonMark Pegram
Dec 17, 2009·Biochimica Et Biophysica Acta·Ryan J O DowlingNahum Sonenberg
Feb 4, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·José BaselgaLuca Gianni
Oct 27, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Fabrice AndreSara A Hurvitz
Jun 22, 2011·Molecular Cancer Therapeutics·Tongrui LiuRuth M O'Regan
Dec 14, 2011·The New England Journal of Medicine·José BaselgaGabriel N Hortobagyi
Mar 21, 2012·Breast Cancer Research : BCR·Keerthi Gogineni, Angela DeMichele
May 7, 2013·Chinese Journal of Cancer·Khurum H KhanDavid Cunningham
Aug 3, 2013·Breast Cancer Research and Treatment·Elisavet PaplomataRuth O'Regan
Jan 29, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Cristina SauraJose Baselga
Mar 26, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ingrid A MayerCarlos L Arteaga
Sep 10, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sibylle LoiblCarsten Denkert
Oct 22, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·José BaselgaSandra M Swain
Jan 7, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Katherine L Pogue-GeileSoonmyung Paik
Jan 7, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ian J MajewskiJosé Baselga
Feb 19, 2015·The New England Journal of Medicine·Sandra M SwainUNKNOWN CLEOPATRA Study Group
Mar 27, 2015·Neoplasia : an International Journal for Oncology Research·Gabriel N Hortobagyi
Apr 15, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Amir AvanSharareh Gholamin
Jul 19, 2015·The Breast : Official Journal of the European Society of Mastology·Sharon T Wilks
Sep 12, 2015·Expert Opinion on Biological Therapy·Francesco PassigliaAntonio Russo
Apr 15, 2016·Journal of the National Cancer Institute·Nathan SimonDavid FitzGerald
Oct 11, 2016·Breast Care·Cornelia Liedtke, Hans-Christian Kolberg
Oct 26, 2016·World Journal of Clinical Oncology·Abolfazl AvanGodefridus J Peters

❮ Previous
Next ❯

Citations

Dec 15, 2017·Journal of Cellular Physiology·Mahdi RivandiAmir Avan
Sep 28, 2018·Journal of Cellular Biochemistry·Safieh EbrahimiKayhan Azadmanesh
Jan 9, 2019·Journal of Molecular Endocrinology·Ayse Basak EnginIpek Isik Gonul
Dec 13, 2019·Current Oncology Reports·Haley Ellis, Cynthia X Ma
Jan 25, 2020·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Dinja T KrugerSabine C Linn
Dec 14, 2018·Therapeutic Advances in Medical Oncology·Siti Muhamad Nur HusnaKah Keng Wong
Feb 14, 2019·International Journal of Molecular Sciences·Tian TianJinhua Zhang
Aug 8, 2019·Breast Cancer Research and Treatment·Jichao HeBob van de Water
Nov 19, 2019·Frontiers in Oncology·Ana Godoy-OrtizEmilio Alba
Dec 25, 2019·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Guang ChenLu-Zhe Sun
Feb 2, 2021·Biochemical and Biophysical Research Communications·Qing WangChunmeng Shi
Oct 9, 2021·Chinese Medical Journal·Zi-Nan LuGang Sun
Dec 18, 2021·International Journal of Immunopathology and Pharmacology·Lobna M AneesAhmed A Elkady

❮ Previous
Next ❯

Related Concepts

Related Feeds

AKT Pathway

This feed focuses on the AKT serine/threonine kinase, which is an important signaling pathway involved in processes such as glucose metabolism and cell survival.