The therapeutic potential of the mesenchymal stem cell secretome in ischaemic stroke

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
Catriona J CunninghamStuart M Allan

Abstract

Mesenchymal stem cells (MSCs) hold great potential as a regenerative therapy for stroke, leading to increased repair and functional recovery in animal models of cerebral ischaemia. While it was initially hypothesised that cell replacement was an important mechanism of action of MSCs, focus has shifted to their paracrine actions or the so called "bystander" effect. MSCs secrete a wide array of growth factors, chemokines, cytokines and extracellular vesicles, commonly referred to as the MSC secretome. There is evidence suggesting the MSC secretome can promote repair through a number of mechanisms including preventing cell apoptosis, modulating the inflammatory response and promoting endogenous repair mechanisms such as angiogenesis and neurogenesis. In this review, we will discuss the in vitro approaches currently being employed to drive the MSC secretome towards a more anti-inflammatory and regenerative phenotype. We will then examine the role of the secretome in promoting repair and improving recovery in preclinical models of cerebral ischaemia.

References

Dec 10, 1999·The Journal of Clinical Investigation·N van BruggenN Ferrara
Oct 6, 2000·The Journal of Clinical Investigation·Z G ZhangM Chopp
Feb 2, 2002·Experimental Hematology·Amelia BartholomewRonald Hoffman
Feb 21, 2002·Proceedings of the National Academy of Sciences of the United States of America·C P HofstetterL Olson
Jul 31, 2002·Journal of Dental Research·S GronthosS Shi
Aug 6, 2002·Experimental Hematology·Yuehua JiangCatherine M Verfaillie
Dec 12, 2002·Molecular Biology of the Cell·Patricia A ZukMarc H Hedrick
Feb 5, 2003·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Xiaoguang ChenMichael Chopp
Feb 5, 2004·Molecular Therapy : the Journal of the American Society of Gene Therapy·Kazuhiko KurozumiHirofumi Hamada
Oct 21, 2004·Blood·Sudeepta Aggarwal, Mark F Pittenger
Dec 8, 2004·Stem Cells·Hwai-Shi WangChin-Chang Chen
Dec 9, 2004·Molecular Therapy : the Journal of the American Society of Gene Therapy·Kazuhiko KurozumiHirofumi Hamada
Jun 2, 2005·Annals of Neurology·Oh Young BangGwang Lee
Sep 6, 2005·Blood·Anna CorcioneAntonio Uccelli
Jan 20, 2006·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Ming-Zhu ZhaoShin-Ichi Miyatake
Apr 6, 2006·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Li Hong ShenMichael Chopp
May 11, 2006·Journal of Cell Science·Lindolfo da Silva MeirellesNance Beyer Nardi
Aug 12, 2006·Brain : a Journal of Neurology·H LiuJ D Kocsis
May 19, 2007·Stroke; a Journal of Cerebral Circulation·Wolf-Rüdiger SchäbitzH Georg Kuhn
Jul 20, 2007·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Toshiyuki OndaJeffery D Kocsis
Oct 24, 2007·Trends in Neurosciences·Knut BiberHendrikus W G M Boddeke
Jan 23, 2008·Stem Cells and Development·Timo SchinkötheAnnette Schmidt
Feb 1, 2008·American Journal of Physiology. Cell Physiology·Paul R CrisostomoDaniel R Meldrum
Apr 10, 2008·Cell Stem Cell·Paolo BiancoPaul J Simmons

❮ Previous
Next ❯

Citations

Oct 24, 2018·CNS Neuroscience & Therapeutics·Xin WangWei-Feng Yu
Sep 5, 2019·Stem Cells Translational Medicine·Su Jing ChanEng H Lo
Dec 5, 2019·International Journal of Molecular Sciences·Roxana SurugiuAurel Popa-Wagner
Jan 23, 2020·Stem Cell Research & Therapy·Catriona J CunninghamStuart M Allan
May 2, 2020·CNS Neuroscience & Therapeutics·Brooke BonsackCesar V Borlongan
May 23, 2020·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Ligen ShiYejie Shi
May 29, 2020·Translational Stroke Research·Assia JaillardUNKNOWN (for the ISIS-HERMES Study Group)
Jul 16, 2020·Journal of Cellular and Molecular Medicine·Raluca TutuianuIrina Titorencu
Sep 25, 2019·International Journal of Molecular Sciences·Milada ChudickovaSarka Kubinova
Apr 17, 2020·Frontiers in Bioengineering and Biotechnology·Þóra SigmarsdóttirÓlafur E Sigurjónsson
Jun 12, 2020·Science Translational Medicine·Nathan Norton Ng, Avnesh Sinh Thakor
Mar 28, 2019·Frontiers in Neurology·Oh Young Bang, Eun Hee Kim
Sep 21, 2018·Frontiers in Neurology·Olivera RajkovicEmmanuel Pinteaux
May 16, 2019·Neural Regeneration Research·Edwin E Reza-ZaldivarAlejandro A Canales-Aguirre
Jul 9, 2020·Molecular Biology Reports·Elena PalàJoan Montaner
Feb 1, 2019·Nature Reviews. Neurology·Zheng Gang ZhangMichael Chopp
Jun 18, 2020·World Journal of Stem Cells·Mariana Penteado NucciLionel Fernel Gamarra
Mar 28, 2020·Stem Cells International·Selma MaachaChiara Cugno
Sep 22, 2018·International Journal of Molecular Sciences·Berta PuigTim Magnus
Nov 12, 2020·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Clemens J Sommer, Wolf-Rüdiger Schäbitz
Nov 4, 2020·Translational Stroke Research·Yinghua JiangXiaoying Wang
Jan 29, 2021·World Journal of Stem Cells·Alberto González-GonzálezFlor M Pérez-Campo
Jan 21, 2021·International Journal of Molecular Sciences·Vitale MiceliPier Giulio Conaldi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Related Papers

Advances in Biochemical Engineering/biotechnology
Stefania BrunoGiovanni Camussi
Tissue Engineering. Part B, Reviews
Yao FuMarcel Karperien
Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics
Yu-Hong TaoZheng Wang
© 2022 Meta ULC. All rights reserved